DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and fzd7

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001016741.1	Gene:	fzd7 / 549495	XenbaseID:	XB-GENE-483731	Length:	548	Species:	Xenopus tropicalis

Alignment Length:	577	Identity:	282/577 - (48%)
Similarity:	360/577 - (62%)	Gaps:	50/577 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMT 69
            :||.|  |:|        |..::..|....|:         .:|.|..|:||:|.:|.:|.||.|
Frog     7 LLFCL--LLQ--------PSPSAQQYHGEKGI---------SVPDHGFCQPISIPLCTDIAYNQT 52

  Fly    70 IMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV- 133
            |||||:|||.||:||||||||.||||:.||.:|:.||||:|.||||:||:.|||||||||.||.
Frog    53 IMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSLCERARQG 117

  Fly   134 CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPH 198
            ||.||..:.|.|||.|.|..||:||..::||.:||:.:     :|:...|:.|.....:....||
Frog   118 CEALMNKFGFQWPERLRCENFPIHGAGEICVGQNTSDN-----SPSGPTARPTPYLPDSITFHPH 177

  Fly   199 RNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVC 257
            .|..|.||.|||.|..:||.. :|.|   ||||||.      .|:|.|.|....|.|||.||.:|
Frog   178 LNRDFTCPRQLKVPPYLGYRF-LGEK---DCGAPCEPGKANGLMYFKEEEVRFARLWVGIWAILC 238

  Fly   258 VASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQ 322
            ..|.||||||:|:|..||.||||.|:||:.||.:|..||.||....:...|.|.|..       .
Frog   239 GISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERFSE-------D 296

  Fly   323 MMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAW 387
            ...|:.||.:: ..||:|||.|||..||:..||..|:..||||||:||||||||..|..|||.||
Frog   297 SYRTVAQGTKK-EGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAW 360

  Fly   388 AVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIR 452
            ||||::||::||:.:|:||||||||:||.....||..|::.||.:||.||..||||||:||||||
Frog   361 AVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIR 425

  Fly   453 TVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCP 517
            |:||.||.:|:|||:||:|||.||.::.:||..:|.|.|||....|.|...|....||.|::|||
Frog   426 TIMKHDGTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTWLVQTCKGFAVPCP 490

  Fly   518 AAR-APGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQ--GK 571
            ... ||.||:    |.:||:|||.:|:||:|||.|::|.||:.|||.|..||.  ||
Frog   491 NYNFAPMSPD----FTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRLSNGGK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	72/116 (62%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	169/327 (52%)
fzd7	NP_001016741.1	CRD_FZ7	32..156	CDD:143575	75/128 (59%)
		Frizzled	218..536	CDD:279827	170/329 (52%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531		2/4 (50%)
		PDZ-binding. /evidence=ECO:0000255	546..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4058
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1160
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm48744
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3233
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110