DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and fzd2

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001008449.1	Gene:	fzd2 / 493345	XenbaseID:	XB-GENE-487022	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	262/536 - (48%)
Similarity:	337/536 - (62%)	Gaps:	40/536 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYV 111
            :|.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.:|:.||||:|.
Frog    34 VPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSSELRFFLCSMYA 98

  Fly   112 PVCTILERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTA 175
            ||||:||:.||||||:||.|| .||.||..:.|.|||.|.|..||.||.|.:||.:|.:....
Frog    99 PVCTVLEQAIPPCRSICERARHGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGG-- 161

  Fly   176 ATPTRSVAKVTTRKHQTGVESP-------HRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPC 233
              ||    .:||.....|...|       |   .|.||..||.|..:.|.. :|.|   ||.|||
Frog   162 --PT----LLTTSPPHHGTPGPPIYATLDH---PFHCPRVLKVPSYLNYRF-LGEK---DCAAPC 213

  Fly   234 HA------MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVV 292
            ..      |||.:.|....|.|:..|:.:|.||..|||.|:|:|..|||||||.|:||:.||.:|
Frog   214 EPSKNDGFMFFSQDEIRFARVWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMV 278

  Fly   293 GCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSC 357
            ..||:||...|:.|.|.|.|..    |..:   |:.||.:: ..||:|||.|||..||:..||..
Frog   279 SVAYIAGFVLGNKVVCNENFSE----GGYK---TVVQGTKK-EGCTILFMMLYFFSMASSIWWVI 335

  Fly   358 LAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSL 422
            |:..||||||:||||||||..|..|||.||||||::||::||:.:::||:||||||||..:...|
Frog   336 LSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPL 400

  Fly   423 GAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLL 487
            ..|::.||.:||.||..||||||:|||||||:||.||.:|:||||||:|||.||.|:.:||..::
Frog   401 RGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVI 465

  Fly   488 GCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWL 552
            .|.|||....:.|...|....||..:||||...   :|...|.|.::|:|||.:::||:||..|:
Frog   466 ACYFYEQAFREHWERSWVSQNCKSLAIPCPLQY---TPRMTPDFTVYMIKYLMTLIVGITSGFWI 527

  Fly   553 YSSKTMVSWRNFVERL 568
            :|.||:.|||.|..||
Frog   528 WSGKTLHSWRKFYTRL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	72/116 (62%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	162/326 (50%)
fzd2	NP_001008449.1	Frizzled	223..540	CDD:279827	162/327 (50%)
fzd2	NP_001008449.1	CRD_FZ2	36..162	CDD:143573	74/129 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4058
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm48744
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060