Protein Alignment fz and fzd6

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_956855.1
• Gene: fzd6 / 393533
• ZFINID: ZDB-GENE-040426-1451
• Length: 617
• Species: Danio rerio
• Alignment Length: 540
• Identity: 210/540 - (38%)
• Similarity: 285/540 - (52%)
• Gaps: 49/540 - (9%)

  Fly    44 LDGLPHHN--RCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFL 106
            ||....|.  .|||:.:..|.::|||.|..||::.|..|:.|.:.:.:|.|||.:.||.|..|||
Zfish    13 LDSCVSHTLFTCEPVQVQWCLDMPYNTTFFPNMLEHYDQDIAAVRMKEFMPLVSVRCSPDAHLFL 77

  Fly   107 CSLYVPVCTILERP------IPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCV 164
            |..:||.|......      :.|||..||..|. |..:|.|::.:||..|:|.:....||
Zfish    78 CQAFVPECRTHSHSQTHTHVLRPCRERCERVRSDCRAVMHTFDISWPSELQCERLESCGG----- 137

  Fly   165 AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDL--H 227
                            |...||| ..::|..|..|::||.||:|||...|.      .|..|  .
Zfish   138 ----------------SAVDVTT-AGRSGAGSSPRDLGFWCPLQLKLRPGQ------SGSFLGAP 179

  Fly   228 DCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVV 292
            ||..||..||....|:.:.|.::|..:.||:.:.|||.||||:|:.|||||||.|||::|||..|
Zfish   180 DCAPPCENMFLTAAEQHLARLFIGVCSVVCLCATLFTFLTFLMDAQRFRYPERPIVFISVCYCAV 244

  Fly   293 GCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSC 357
            ...|:.|...|.||:|..|       ||...:.|:..|.| :..|::||..||||..|...||..
Zfish   245 SLLYLLGFMLGPSVACGAP-------GRPGGVWTVVLGAR-SRGCSLLFTLLYFCSTAGMLWWVI 301

  Fly   358 LAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSL 422
            |...||||||.||..|||:.::..||...|.|||:.|:.:|||.|||||.:|||||.|..|..:|
Zfish   302 LTITWFLAAGPKWSCEAIQKQALWFHAAGWGVPAVLTLLLLALGKVEGDGISGVCFTGLYDLTAL 366

  Fly   423 GAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLL 487
            ..||:.||.:.:.:|...||||.::|.|:|.|::.|.....||:|.|:|||.||||::||.:.||
Zfish   367 RWFLVAPLALAVLLGLALLLAGIVALNRVRQVIQHDQLNQQKLKRFMIRIGVFSGLYLLPLLLLL 431

  Fly   488 GCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWL 552
            ||..||......|...|....|:.|||||  ||........|...:|::|||.::.||:.:..|:
Zfish   432 GCYLYEMTQRRVWESSWVNRHCQEFSIPC--ARTSSGGVQHPGLSLFLLKYLMTLAVGIPAVFWV 494

  Fly   553 YSSKTMVSWRNFVERLQGKE 572
            .|.||...|.:|..|...|:
Zfish   495 SSRKTCSRWASFCRRAHKKD 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	42/124 (34%)
		Frizzled	237..564	CDD:279827	140/326 (43%)
fzd6	NP_956855.1	CRD_FZ6	20..154	CDD:143559	48/155 (31%)
		7tm_GPCRs	188..508	CDD:391938	142/329 (43%)
		TM helix 1	198..222	CDD:341315	10/23 (43%)
		TM helix 2	231..252	CDD:341315	10/20 (50%)
		TM helix 3	282..304	CDD:341315	10/21 (48%)
		TM helix 4	325..341	CDD:341315	7/15 (47%)
		TM helix 5	363..386	CDD:341315	6/22 (27%)
		TM helix 6	414..439	CDD:341315	15/24 (63%)
		TM helix 7	469..494	CDD:341315	7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020