Protein Alignment fz and smo

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 155/598 - (25%)
• Similarity: 264/598 - (44%)
• Gaps: 124/598 - (20%)

  Fly    23 PLDASPYYRSGGGLMASSGTE----LDGLPHHN-------RCEPIT--ISIC--KNIPYNMTIMP 72
            |::.:..||    |.|..|.:    .|||...:       ||.|.:  .:.|  ..:||.::.:.
  Fly    53 PINGTLNYR----LYAKKGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLD 113

  Fly    73 NLIGHTKQEEAGLEVHQFAPLVKI-GCSDDLQLFLCSLYVPVCTILERP----IPP---CRSLCE 129
            ....|| ::|...:::.:..|..: .|...:|.|||:::.|.|..:...    :|.   ||...|
  Fly   114 LTDFHT-EKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITME 177

  Fly   130 SARVCEKLMKTYNFN-WPENLECSK--FP---VHGGEDLCVAENTTSSASTAATPTRSVAKVTTR 188
            ..|:      .||.. :|:.|.|::  ||   .:|...:  ..|.|....:...||.     |:.
  Fly   178 PCRI------LYNTTFFPKFLRCNETLFPTKCTNGARGM--KFNGTGQCLSPLVPTD-----TSA 229

  Fly   189 KHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSW 253
            .:..|:|.                                ||..|....:.:.|...:...:| |
  Fly   230 SYYPGIEG--------------------------------CGVRCKDPLYTDDEHRQIHKLIG-W 261

  Fly   254 A-AVCVASCLFTVLTFLID-SSRFRYPERAIVFLAVCYLV--VGCAYVAGLGAGDSVSCREPFPP 314
            | ::|:.|.||.|.||.|| .:..:||...:.::.:|:|:  ||.......|:.:.:.||
  Fly   262 AGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR----- 321

  Fly   315 PVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGH--EAIEN 377
              |.|.|: .|..|.|  :..||.|:|:.:|:...|...|:..|.:||...|   .||  :.|:.
  Fly   322 --KDGTLR-HSEPTAG--ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDK 378

  Fly   378 KSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLIL-PLCIYLSIGALFL 441
            |...||||||::|.:.||:.:|.::|:|:.:.|:||||.:: ||:.|.|:| |||..:.||..|:
  Fly   379 KGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYIN-HSMRAGLLLGPLCGVILIGGYFI 442

  Fly   442 LAGFISLFRIRTVMKTDGKRT---DKLERLMLRIG---FFSGLFILPAVGLLGCLFYEYYNFDEW 500
            ..|.:.||.::. ...|.|.|   :|:..:::|:|   ..:.:|||.|:   .|...|:.:.|||
  Fly   443 TRGMVMLFGLKH-FANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI---ACHVTEFRHADEW 503

  Fly   501 MIQWHR-DICKPFSI-----PCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMV 559
            ...:.: .|||..|:     .|..       |.||...:..:..||....|:..|.|.::..::.
  Fly   504 AQSFRQFIICKISSVFEEKSSCRI-------ENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIE 561

  Fly   560 SWRNFVERLQGKE 572
            :|:.::.:..|||
  Fly   562 TWKRYIRKKCGKE 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	30/140 (21%)
		7tmF_FZD1_insect	236..568	CDD:320376	103/350 (29%)
		TM helix 1	245..270	CDD:320376	10/25 (40%)
		TM helix 2	279..300	CDD:320376	4/22 (18%)
		TM helix 3	338..364	CDD:320376	8/25 (32%)
		TM helix 4	381..397	CDD:320376	9/15 (60%)
		TM helix 5	419..448	CDD:320376	12/29 (41%)
		TM helix 6	468..495	CDD:320376	8/29 (28%)
		TM helix 7	527..552	CDD:320376	6/24 (25%)
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	32/143 (22%)
		7tmF_SMO_homolog	245..568	CDD:320158	103/348 (30%)
		TM helix 1	254..279	CDD:320158	10/25 (40%)
		TM helix 2	289..310	CDD:320158	4/20 (20%)
		TM helix 3	340..366	CDD:320158	8/25 (32%)
		TM helix 4	382..398	CDD:320158	9/15 (60%)
		TM helix 5	420..449	CDD:320158	12/28 (43%)
		TM helix 6	471..498	CDD:320158	8/29 (28%)
		TM helix 7	529..554	CDD:320158	6/24 (25%)