DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and Smo

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_795970.3	Gene:	Smo / 319757	MGIID:	108075	Length:	793	Species:	Mus musculus

Alignment Length:	601	Identity:	161/601 - (26%)
Similarity:	256/601 - (42%)	Gaps:	133/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SGGGLMASSGTELDGLP----------HHNR---CEPITISIC--KNIPYNMTIMPNLIGHTKQE 81
            :|.|..::||:....:|          |..|   |||:..::|  ..:||..|..........||
Mouse    40 TGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQE 104

  Fly    82 EA--------GLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESAR----VC 134
            ||        ||   :.||    .|...:|..||::|:|.|. .:|...|.|:||::.|    :.
Mouse   105 EAHGKLVLWSGL---RNAP----RCWAVIQPLLCAVYMPKCE-NDRVELPSRTLCQATRGPCAIV 161

  Fly   135 EKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHR 199
            |:     ...||:.|.|:  |.|..|                                |..:..:
Mouse   162 ER-----ERGWPDFLRCT--PDHFPE--------------------------------GCPNEVQ 187

  Fly   200 NIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFT 264
            ||.|....|.:.||......|...:|:..||..|....|.|.|...:..::.::.||.....|||
Mouse   188 NIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFT 252

  Fly   265 VLTFLID-SSRFRYPERAIVFLAVCYLVVGCAYVAGL--GAGDSVSCREP----FPPPVKLGRLQ 322
            :.||:.| .:..|||...:.::..|:.|....::|..  ||...:.||..    |..|..
Mouse   253 LATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTS----- 312

  Fly   323 MMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAW---FLAAGLKWGHEAIENKSHLFHL 384
                     .:|.||.::|:.:|:..||...|:..|.:||   |.|.|..  ::.:..|:..|||
Mouse   313 ---------SETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTT--YQPLSGKTSYFHL 366

  Fly   385 VAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLF 449
            :.|::|.:.|:::||:|:|:||.:||:||||..:......|::.|:.:.|.:|..||:.|.::||
Mouse   367 LTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLF 431

  Fly   450 RIRTVMKTDG----KRTDKLERLMLRIGFFSGL---FILPAVGLLGCLFYEYYNFDEWMIQWHRD 507
            .|::  ...|    |...|:...|||:|.|..|   |:|..   ..|.||:::|..||...: ||
Mouse   432 SIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLIT---FSCHFYDFFNQAEWERSF-RD 490

  Fly   508 ICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLV-----------GVTSSVWLYSSKTMVSW 561
            .     :.|.|....|.|..:||... .:|...|:||           |:..|.|:::..|::.|
Mouse   491 Y-----VLCQANVTIGLPTKKPIPDC-EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIW 549

  Fly   562 RNFVERLQG---KEPR 574
            |....||.|   .||:
Mouse   550 RRTWCRLTGHSDDEPK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	37/132 (28%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	101/354 (29%)
Smo	NP_795970.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..61		5/20 (25%)
		CRD_SMO	70..200	CDD:143560	42/176 (24%)
		Frizzled	225..554	CDD:279827	101/356 (28%)
		Interaction with BBS5 and BBS7. /evidence=ECO:0000269\|PubMed:22072986	542..573		8/24 (33%)
		Interaction with DLG5. /evidence=ECO:0000269\|PubMed:25644602	585..597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810