DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and fz3

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	135/562 - (24%)
Similarity:	226/562 - (40%)	Gaps:	106/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESAR-VC----- 134
            :...:|.| ::.:..||::.|||...:..|||...|:|| .:.||:..|:.|||:.| .|
  Fly   130 YKSDDEKG-QIAKLVPLIESGCSRRARFLLCSSLFPLCTPDVPRPVAACKLLCETVRGECMENAP 193

  Fly   135 EKLMKTYNFNWPENLECSKFPVHGGEDLCV---AENTTSSASTAATPTRSVAKV-----TTRKHQ 191
            .:||:.    ||..|.|...|.....:||:   .|......|.:..||.....|     |.|..:
  Fly   194 PELMEL----WPSFLNCDGLPQPEKHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWK 254

  Fly   192 TGVESPHRNIGFVCPVQLK-TPLGMGYELKVGGKDLHDCGAPCHA-MFFPERERTVLRYWVGSWA 254
            :|........|.:||.... :|.           :..:|...|.. .|....::......:...:
  Fly   255 SGASPTSDLAGVLCPQNFSGSPF-----------NPEECVPQCQRDAFHTSSQKKTSETLILGLS 308

  Fly   255 AVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLG 319
            |||....||.::||..:.:||.||||.::||.:||.:....|:.          |..|....::.
  Fly   309 AVCFVLTLFALVTFWAEPTRFGYPERPVLFLCLCYNLFSVCYLE----------RIVFHNQARMH 363

  Fly   320 RLQMMSTITQ-GHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFH 383
            .:::...:.: |...|..|...::...:..:.|.:||...|..::|::..||..||:|.:|.|||
  Fly   364 DVELQWRLMRPGCLLTPPCLASYITTSYLSLCAASWWLIFALCFYLSSHKKWSSEALEKRSGLFH 428

  Fly   384 LVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISL 448
            ::||..|....|:.|.|.||....|:|:|:.        ..|:.||..:.|.:|..|.|....||
  Fly   429 VLAWVPPLAPPIAALLLEKVRPSELTGMCYA--------PGFVELPALVLLLLGLYFTLRASRSL 485

  Fly   449 FRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILP-AVGLLGCLFYEYYNFDEWMIQWHRDICKPF 512
            ..::..::.. ....:..::..|...||.|:..| ..|::..|                  |:.:
  Fly   486 LSLQQQLQPT-LAHHRFGQIRKRFVLFSLLYFAPTTAGVVAAL------------------CERY 531

  Fly   513 SIPCPAARAPG---SP---EARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFV------ 565
            :...|:...|.   ||   .|.|.    :|:....::.|..:.:|::|.||..|:||.:
  Fly   532 ADSVPSCSTPDDCLSPTPLSAWPA----LVRIFFQLVGGTLTGLWVWSRKTCESYRNRLGASGTP 592

  Fly   566 -------ERLQGKEPRTRAQAYVXYETG----PAGGAKSTPL 596
                   .:..|..|:..      |.:|    |.||.  |||
  Fly   593 TSSLMNQSKAAGALPKKH-----LYTSGKSMLPTGGI--TPL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	30/99 (30%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	80/334 (24%)
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	28/89 (31%)
		Frizzled	291..584	CDD:279827	79/333 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850