DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and fzd7b

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_739569.1	Gene:	fzd7b / 30412	ZFINID:	ZDB-GENE-990415-229	Length:	557	Species:	Danio rerio

Alignment Length:	583	Identity:	270/583 - (46%)
Similarity:	364/583 - (62%)	Gaps:	46/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIP 65
            :::.....:.||:.|:         :|..|....|:         .:|.|..|:||:|.:|.:|.
Zfish    11 VYKTYCVFITTLLFGL---------SSAQYHGEKGI---------SVPEHGFCQPISIPLCTDIQ 57

  Fly    66 YNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCES 130
            ||.||||||:|||.||:||||||||.||||:.||.||:.||||:|.||||:||:.|||||:|||.
Zfish    58 YNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTVLEQAIPPCRTLCER 122

  Fly   131 ARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGV 194
            ||. ||.||..:.|.|||.|.|..|||||..::||.:|.:........||..:.:..:.:    :
Zfish   123 ARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNKSDPDVPTTNPTPYIPEPFSPR----I 183

  Fly   195 ESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSW 253
            .:|.:|..|.||:||..|..:.|.. :|.|   :|||||.      .|:|.|.|....|.|||.|
Zfish   184 HTPRQNQAFTCPLQLTVPSYLNYHF-LGAK---NCGAPCEHKQPYGLMYFKEEEVRFGRLWVGIW 244

  Fly   254 AAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKL 318
            :.:|..|.||||||:|:|..||.||||.|:||:.||.:|..||.||....|.|.|.:.|
Zfish   245 SILCCVSTLFTVLTYLVDMRRFHYPERPIIFLSGCYFMVAVAYAAGFLLEDKVVCIDKF------ 303

  Fly   319 GRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFH 383
             |.....|:.||.:: ..||:|||.|||..||:..||..|:..|||:||:||||||||..|..||
Zfish   304 -RDDAFKTVAQGTKK-EGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFH 366

  Fly   384 LVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISL 448
            |.||||||::||::|||.:|:||:|:|||:||..:..:|..|::.||.:||.||..||||||:||
Zfish   367 LAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGFVSL 431

  Fly   449 FRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFS 513
            |||||:||.||.:|:|||:||:|||.||.|:.:||..::.|.|||....::|...||...||.|:
Zfish   432 FRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHMQTCKRFA 496

  Fly   514 IPCPAAR-APGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRT 575
            :|||... ||.:|:    |.:||:|||.:|:||:||..|::|.||:.|||.|.:||...:..|
Zfish   497 VPCPNNNFAPMTPD----FTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRLGNNQGET 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	73/116 (63%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	165/327 (50%)
fzd7b	NP_739569.1	CRD_FZ1_like	43..161	CDD:143567	73/117 (62%)
fzd7b	NP_739569.1	Frizzled	228..545	CDD:279827	165/328 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4077
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20750
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1115
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm24936
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3233
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870