Protein Alignment fz and fzd2

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_571215.1
• Gene: fzd2 / 30370
• ZFINID: ZDB-GENE-990415-224
• Length: 550
• Species: Danio rerio
• Alignment Length: 562
• Identity: 269/562 - (47%)
• Similarity: 350/562 - (62%)
• Gaps: 51/562 - (9%)

  Fly    26 ASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQF 90
            ||..::...|:         .:|.|..|:||||.:|.:|.||.||||||:||..||:||||||||
Zfish    21 ASGQHQGDNGI---------AVPDHGFCQPITIPLCTDIAYNQTIMPNLVGHYNQEDAGLEVHQF 76

  Fly    91 APLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKF 154
            .||||:.||.:|:.||||:|.||||:||:.||||||:||.|:. ||.||..:.|.|||.|.|..|
Zfish    77 YPLVKVQCSPELKFFLCSMYAPVCTVLEKAIPPCRSICERAKQGCEVLMNKFGFQWPEALRCEHF 141

  Fly   155 PVHGGEDLCVAEN----TTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGM 215
            ||.|...:||.:|    |.|........|.||...:|      .:.|.|     ||..||.|..:
Zfish   142 PVLGDGHICVGQNDSMATVSPVHMPIPGTPSVQLYST------PDKPFR-----CPSTLKVPAYL 195

  Fly   216 GYELKVGGKDLHDCGAPCHA-------MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSS 273
            .|  |..|:.  ||||||.:       |||.::|....|.|:..|:::|.||.||||.|:::|..
Zfish   196 SY--KFLGEP--DCGAPCESSRTHRAYMFFTDQEIEFARIWILIWSSLCCASTLFTVTTYIVDMQ 256

  Fly   274 RFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCT 338
            ||:||||.|:||:.||.:|..||:||...||.|.|.|.|.|       ....||.||.:: ..||
Zfish   257 RFKYPERPIIFLSGCYTMVSIAYIAGYFLGDKVVCNESFFP-------DSYKTIVQGTKK-EGCT 313

  Fly   339 VLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKV 403
            :|||.|||..||:..||..|:..||||||:||||||||..|..|||.||||||::|||:||:.::
Zfish   314 ILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQI 378

  Fly   404 EGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERL 468
            :||:||||||||..::.:|..|::.||.:||.||..||||||:|||||||:||.||.:|:|||||
Zfish   379 DGDVLSGVCFVGLNNSDALRGFILAPLFLYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERL 443

  Fly   469 MLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQI 533
            |:|||.||.|:.:||..::.|.|||.....:|...|....||..:||||...|   |...|.|.:
Zfish   444 MVRIGVFSVLYTVPATIVIACFFYEQAFRQQWEKSWISMNCKSLAIPCPMQPA---PHMTPDFTV 505

  Fly   534 FMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL----QGK 571
            ||:|||.:::||:||..|::|.||:.||:.|..||    ||:
Zfish   506 FMIKYLMTLIVGITSGFWIWSGKTLHSWQKFYVRLTSAGQGE 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	70/116 (60%)
		7tmF_FZD1_insect	236..568	CDD:320376	167/331 (50%)
		TM helix 1	245..270	CDD:320376	11/24 (46%)
		TM helix 2	279..300	CDD:320376	11/20 (55%)
		TM helix 3	338..364	CDD:320376	13/25 (52%)
		TM helix 4	381..397	CDD:320376	11/15 (73%)
		TM helix 5	419..448	CDD:320376	14/28 (50%)
		TM helix 6	468..495	CDD:320376	14/26 (54%)
		TM helix 7	527..552	CDD:320376	11/24 (46%)
fzd2	NP_571215.1	CRD_FZ1_like	37..154	CDD:143567	70/116 (60%)
		7tmF_FZD2	219..548	CDD:320373	171/340 (50%)
		TM helix 1	228..253	CDD:320373	11/24 (46%)
		TM helix 2	262..283	CDD:320373	11/20 (55%)
		TM helix 3	313..339	CDD:320373	13/25 (52%)
		TM helix 4	356..372	CDD:320373	11/15 (73%)
		TM helix 5	394..423	CDD:320373	14/28 (50%)
		TM helix 6	443..470	CDD:320373	14/26 (54%)
		TM helix 7	499..524	CDD:320373	11/24 (46%)