DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and fzd7a

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_571214.2	Gene:	fzd7a / 30369	ZFINID:	ZDB-GENE-990415-223	Length:	559	Species:	Danio rerio

Alignment Length:	537	Identity:	273/537 - (50%)
Similarity:	354/537 - (65%)	Gaps:	31/537 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYV 111
            :|.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.||:.||||:|.
Zfish    39 IPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYA 103

  Fly   112 PVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTA 175
            ||||:||:.|||||||||.||. ||.||..:.|.|||.|.|..|||||..::||.:||:.:.|..
Zfish   104 PVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPT 168

  Fly   176 ATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------ 234
            :.||..|.::.|.:....|..   |..|.||:|||.|..:.|.. :|.|   ||||||.
Zfish   169 SNPTPYVPELITLQPNLVVRP---NQQFTCPLQLKVPTYLKYHF-MGEK---DCGAPCEPTRPNG 226

  Fly   235 AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAG 299
            .|:|.|.|....|.|||.|:.:|..|.||||||:|:|..|||||||.|:||:.||.:|..||.||
Zfish   227 LMYFREEEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAG 291

  Fly   300 LGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            ....|.|.|.:.|..       ....|:.||.:: ..||:|||.|||..||:..||..|:..|||
Zfish   292 FFLEDKVVCIDKFSD-------DGYKTVAQGTKK-EGCTILFMILYFFGMASSIWWVILSLTWFL 348

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            :||:||||||||..|..|||.||||||::||::||:.:|:||:|:|||:||..:..||..|::.|
Zfish   349 SAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAP 413

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            |.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:.:||..::.|.|||.
Zfish   414 LFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQ 478

  Fly   495 YNFDEWMIQWHRDICKPFSIPCPAAR-APGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTM 558
            ...::|...||...||.|::|||... ||.||:    |.:||:|||.:|:||:||..|::|.||:
Zfish   479 AFREQWEKTWHMQTCKRFAVPCPVNNFAPMSPD----FTVFMIKYLMTMIVGITSGFWIWSGKTL 539

  Fly   559 VSWRNFVERL----QGK 571
            .|||.|.:||    ||:
Zfish   540 QSWRRFYKRLSNSNQGE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	74/116 (64%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	166/327 (51%)
fzd7a	NP_571214.2	CRD_FZ	41..163	CDD:382974	77/121 (64%)
		7tm_GPCRs	228..558	CDD:391938	172/341 (50%)
		TM helix 1	238..262	CDD:341315	13/23 (57%)
		TM helix 2	271..292	CDD:341315	11/20 (55%)
		TM helix 3	322..344	CDD:341315	12/21 (57%)
		TM helix 4	365..381	CDD:341315	11/15 (73%)
		TM helix 5	403..426	CDD:341315	10/22 (45%)
		TM helix 6	454..479	CDD:341315	12/24 (50%)
		TM helix 7	508..533	CDD:341315	13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4077
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20750
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1115
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm24936
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3233
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870