Protein Alignment fz and fzd7a

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_571214.2
• Gene: fzd7a / 30369
• ZFINID: ZDB-GENE-990415-223
• Length: 559
• Species: Danio rerio
• Alignment Length: 537
• Identity: 273/537 - (50%)
• Similarity: 354/537 - (65%)
• Gaps: 31/537 - (5%)

  Fly    47 LPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYV 111
            :|.|..|:||:|.:|.:|.||.||||||:|||.||:||||||||.||||:.||.||:.||||:|.
Zfish    39 IPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYA 103

  Fly   112 PVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTA 175
            ||||:||:.|||||||||.||. ||.||..:.|.|||.|.|..|||||..::||.:||:.:.|..
Zfish   104 PVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPT 168

  Fly   176 ATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------ 234
            :.||..|.::.|.:....|..   |..|.||:|||.|..:.|.. :|.|   ||||||.
Zfish   169 SNPTPYVPELITLQPNLVVRP---NQQFTCPLQLKVPTYLKYHF-MGEK---DCGAPCEPTRPNG 226

  Fly   235 AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAG 299
            .|:|.|.|....|.|||.|:.:|..|.||||||:|:|..|||||||.|:||:.||.:|..||.||
Zfish   227 LMYFREEEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAG 291

  Fly   300 LGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            ....|.|.|.:.|..       ....|:.||.:: ..||:|||.|||..||:..||..|:..|||
Zfish   292 FFLEDKVVCIDKFSD-------DGYKTVAQGTKK-EGCTILFMILYFFGMASSIWWVILSLTWFL 348

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            :||:||||||||..|..|||.||||||::||::||:.:|:||:|:|||:||..:..||..|::.|
Zfish   349 SAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAP 413

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            |.:||.||..||||||:|||||||:||.||.:|:|||:||:|||.||.|:.:||..::.|.|||.
Zfish   414 LFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQ 478

  Fly   495 YNFDEWMIQWHRDICKPFSIPCPAAR-APGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTM 558
            ...::|...||...||.|::|||... ||.||:    |.:||:|||.:|:||:||..|::|.||:
Zfish   479 AFREQWEKTWHMQTCKRFAVPCPVNNFAPMSPD----FTVFMIKYLMTMIVGITSGFWIWSGKTL 539

  Fly   559 VSWRNFVERL----QGK 571
            .|||.|.:||    ||:
Zfish   540 QSWRRFYKRLSNSNQGE 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	74/116 (64%)
		7tmF_FZD1_insect	236..568	CDD:320376	168/332 (51%)
		TM helix 1	245..270	CDD:320376	13/24 (54%)
		TM helix 2	279..300	CDD:320376	11/20 (55%)
		TM helix 3	338..364	CDD:320376	13/25 (52%)
		TM helix 4	381..397	CDD:320376	11/15 (73%)
		TM helix 5	419..448	CDD:320376	15/28 (54%)
		TM helix 6	468..495	CDD:320376	14/26 (54%)
		TM helix 7	527..552	CDD:320376	11/24 (46%)
fzd7a	NP_571214.2	CRD_FZ	41..163	CDD:470581	77/121 (64%)
		7tm_GPCRs	228..558	CDD:475119	172/341 (50%)
		TM helix 1	238..262	CDD:320374	13/23 (57%)
		TM helix 2	271..292	CDD:320374	11/20 (55%)
		TM helix 3	322..344	CDD:320374	12/21 (57%)
		TM helix 4	365..381	CDD:320374	11/15 (73%)
		TM helix 5	403..426	CDD:320374	10/22 (45%)
		TM helix 6	457..479	CDD:320374	10/21 (48%)
		TM helix 7	508..533	CDD:320374	13/28 (46%)