Protein Alignment fz and fzd10

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_570992.2
• Gene: fzd10 / 30366
• ZFINID: ZDB-GENE-990415-220
• Length: 580
• Species: Danio rerio
• Alignment Length: 602
• Identity: 233/602 - (38%)
• Similarity: 330/602 - (54%)
• Gaps: 87/602 - (14%)

  Fly    35 GLMASSG-----TELD-GLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPL 93
            ||:..:|     :.:| ..|...||:.|.|.:||:|.||:|:||||:||..|.||.:::|:||||
Zfish    11 GLLCFAGFCSAISSIDPDRPGEGRCQEIAIPLCKDIGYNLTVMPNLMGHEDQNEAAIKLHEFAPL 75

  Fly    94 VKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFPV 156
            ::.||...|:.||||||.|:|| .:..|||.||.:||.|| .|..:|:.:||:|||:|:||:.|.
Zfish    76 IEFGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPN 140

  Fly   157 HGGED-LCV-AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYEL 219
            ....: ||: |.|                        .|.:.|.:......|.......|...||
Zfish   141 KNDPNYLCMEAPN------------------------NGTDEPPKGSHTQSPDSRPPRPGNSQEL 181

  Fly   220 ----KVG-------GKDLH------DCGAPCHA---MFFPERERTVLRYWVGSWAAVCVASCLFT 264
                :||       || .|      .|...|::   :::.:.::.....|:..|:.:|..|..||
Zfish   182 PIKERVGKTTCSNPGK-FHYVQKSESCAPKCYSNVDVYWSQGDKRFSMVWIAIWSILCFISSAFT 245

  Fly   265 VLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTIT 328
            |||||||..||:||||.|:||::.|.|....::..|..| ::|:|          .|...:..|.
Zfish   246 VLTFLIDPQRFKYPERPIIFLSMSYCVYSVGFLVRLFVGVENVAC----------DRDTGVQYII 300

  Fly   329 QGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQ 393
            |...::|.||::|:.||:..||:..||..|...||||||.||||||||..|..|||.|||:||::
Zfish   301 QEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAIK 365

  Fly   394 TISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTD 458
            ||.:|.:.||.||.|:|||:||.:|..:|..|:::||..||.||..|||:||::||.||.||||:
Zfish   366 TIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVALFHIRKVMKTE 430

  Fly   459 GKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPG 523
            |:.|||||:||:|||.||.|:.:||..::.|.|||..|.|.|.|......|        |.....
Zfish   431 GENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKILAGEQKC--------ADDGKS 487

  Fly   524 SPE-----ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXY 583
            ..|     :.|..:|||||....::||:||.:|:::|||:.||:|...|...|:.|.:| |.|..
Zfish   488 GEECVMKSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVFSRKLKKKTRRKA-ACVFT 551

  Fly   584 ETGPAGGAKSTPLTPDP 600
            .:||.       |.|.|
Zfish   552 GSGPY-------LKPHP 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	59/119 (50%)
		7tmF_FZD1_insect	236..568	CDD:320376	144/337 (43%)
		TM helix 1	245..270	CDD:320376	10/24 (42%)
		TM helix 2	279..300	CDD:320376	7/20 (35%)
		TM helix 3	338..364	CDD:320376	10/25 (40%)
		TM helix 4	381..397	CDD:320376	10/15 (67%)
		TM helix 5	419..448	CDD:320376	13/28 (46%)
		TM helix 6	468..495	CDD:320376	14/26 (54%)
		TM helix 7	527..552	CDD:320376	10/24 (42%)
fzd10	NP_570992.2	CRD_FZ	31..157	CDD:470581	61/149 (41%)
		7tmF_FZD10	217..535	CDD:320165	144/335 (43%)
		TM helix 1	226..251	CDD:320165	10/24 (42%)
		TM helix 2	260..281	CDD:320165	7/20 (35%)
		TM helix 3	310..336	CDD:320165	10/25 (40%)
		TM helix 4	353..369	CDD:320165	10/15 (67%)
		TM helix 5	391..420	CDD:320165	13/28 (46%)
		TM helix 6	440..467	CDD:320165	14/26 (54%)
		TM helix 7	496..521	CDD:320165	10/24 (42%)