DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and Corin

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	153	Identity:	56/153 - (36%)
Similarity:	81/153 - (52%)	Gaps:	8/153 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAG 84
            |:..||:|......|..:..|.:.|....|   |||||:.:|.|:|||:|..||.:||..|:||.
  Rat   491 DRGCLDSSCVESCAGSSLCDSDSSLSNCSH---CEPITLELCMNLPYNLTHYPNYLGHRTQKEAS 552

  Fly    85 L--EVHQFAPLVKIGCSDDLQLFLCSLYVPVCTI-LERPIPPCRSLCE-SARVCEKLMKTYNFNW 145
            :  |...|..||:..|...|..|.|::.||.|.: ..:.:||||.||| |...||.::......|
  Rat   553 ISWESALFPALVQTNCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQW 617

  Fly   146 PENLECSKFPVHGGED-LCVAEN 167
            ||:.:||:||....:: .|:..|
  Rat   618 PEDTDCSQFPEQSSDNQTCLLPN 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	47/120 (39%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579	48/120 (40%)
		Ldl_recept_a	646..680	CDD:395011
		LDLa	<693..718	CDD:238060
		LDLa	721..755	CDD:238060
		SRCR_2	779..859	CDD:413346
		Tryp_SPc	867..1098	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810