DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and Fzd3

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_703204.1	Gene:	Fzd3 / 266715	RGDID:	628814	Length:	666	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	223/559 - (39%)
Similarity:	306/559 - (54%)	Gaps:	56/559 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:.:|:::|||.|.||||:.|..|:.|.|.:..|.|:|.:.||.|.:.|||:||.|:|...
  Rat    28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEY 92

  Fly   118 ERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFP---------VHGGEDLCVAENTTSSA 172
            .|...|||.||:.| ..|.|||:.:...|||::|||:||         |    ||.:..:.|..|
  Rat    93 GRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLV----DLNLVGDPTEGA 153

  Fly   173 STAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLH--DCGAPCHA 235
            ..|.                     .|:.||.||.:||....:||..      ||  ||..||..
  Rat   154 PVAV---------------------QRDYGFWCPRELKIDPDLGYSF------LHVRDCSPPCPN 191

  Fly   236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGL 300
            |:|...|.:..||::|..:.:|:::.|.|.||||||.:|||||||.|:|.||||::|...:..|.
  Rat   192 MYFRREELSFARYFIGLISIICLSATLVTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF 256

  Fly   301 GAGDSVSCREPFPPPVKLGRLQMMSTITQG-HRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            ...|.|:|....|...|      .||:||| |.:  :||:|||.|||..||...||..|...|||
  Rat   257 LLEDRVACNASSPAQYK------ASTVTQGSHNK--ACTMLFMVLYFFTMAGSVWWVILTITWFL 313

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            ||..|||.||||.|:.|||..||.:|...||.:||:.|:|||.:|||||||..|..:|..|::.|
  Rat   314 AAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAP 378

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            ||:|:.:|...||||.|||.|:|..:..:.:..|||.:.|:|||.||.|:::|.:.::||.|||.
  Rat   379 LCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQ 443

  Fly   495 YNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMV 559
            .....|...|.::.|:.:.||||......|   ||...:|::|||.:::||:.|..|:.|.||..
  Rat   444 AYRGIWETTWIQERCREYHIPCPYQVTQMS---RPDLILFLMKYLMALIVGIPSIFWVGSKKTCF 505

  Fly   560 SWRNFVERLQGKEPRTRAQAYVXYETGPAGGAKSTPLTP 598
            .|.:|....:.||....:: .| .|...|......|.||
  Rat   506 EWASFFHGRKKKETVNESR-QVLQEPDFAQSLLRDPNTP 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	53/123 (43%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	142/327 (43%)
Fzd3	NP_703204.1	CRD_FZ3	24..150	CDD:143558	53/125 (42%)
Fzd3	NP_703204.1	Frizzled	193..512	CDD:279827	143/329 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920