Protein Alignment fz and Fzd3

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_703204.2
• Gene: Fzd3 / 266715
• RGDID: 628814
• Length: 666
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 224/559 - (40%)
• Similarity: 307/559 - (54%)
• Gaps: 56/559 - (10%)

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:.:|:::|||.|.||||:.|..|:.|.|.:..|.|:|.:.||.|.:.|||:||.|:|...
  Rat    28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEY 92

  Fly   118 ERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFP---------VHGGEDLCVAENTTSSA 172
            .|...|||.||:.| ..|.|||:.:...|||::|||:||         |    ||.:..:.|..|
  Rat    93 GRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLV----DLNLVGDPTEGA 153

  Fly   173 STAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLH--DCGAPCHA 235
            ..|.                     .|:.||.||.:||....:||..      ||  ||..||..
  Rat   154 PVAV---------------------QRDYGFWCPRELKIDPDLGYSF------LHVRDCSPPCPN 191

  Fly   236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGL 300
            |:|...|.:..||::|..:.:|:::.|||.||||||.:|||||||.|:|.||||::|...:..|.
  Rat   192 MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF 256

  Fly   301 GAGDSVSCREPFPPPVKLGRLQMMSTITQG-HRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            ...|.|:|....|...|      .||:||| |.:  :||:|||.|||..||...||..|...|||
  Rat   257 LLEDRVACNASSPAQYK------ASTVTQGSHNK--ACTMLFMVLYFFTMAGSVWWVILTITWFL 313

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            ||..|||.||||.|:.|||..||.:|...||.:||:.|:|||.:|||||||..|..:|..|::.|
  Rat   314 AAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAP 378

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            ||:|:.:|...||||.|||.|:|..:..:.:..|||.:.|:|||.||.|:::|.:.::||.|||.
  Rat   379 LCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQ 443

  Fly   495 YNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMV 559
            .....|...|.::.|:.:.||||......|   ||...:|::|||.:::||:.|..|:.|.||..
  Rat   444 AYRGIWETTWIQERCREYHIPCPYQVTQMS---RPDLILFLMKYLMALIVGIPSIFWVGSKKTCF 505

  Fly   560 SWRNFVERLQGKEPRTRAQAYVXYETGPAGGAKSTPLTP 598
            .|.:|....:.||....:: .|..|...|......|.||
  Rat   506 EWASFFHGRKKKETVNESR-QVLQEPDFAQSLLRDPNTP 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	53/123 (43%)
		7tmF_FZD1_insect	236..568	CDD:320376	145/332 (44%)
		TM helix 1	245..270	CDD:320376	10/24 (42%)
		TM helix 2	279..300	CDD:320376	9/20 (45%)
		TM helix 3	338..364	CDD:320376	13/25 (52%)
		TM helix 4	381..397	CDD:320376	8/15 (53%)
		TM helix 5	419..448	CDD:320376	12/28 (43%)
		TM helix 6	468..495	CDD:320376	13/26 (50%)
		TM helix 7	527..552	CDD:320376	9/24 (38%)
Fzd3	NP_703204.2	None