DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and Fzd9

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_695217.1	Gene:	Fzd9 / 266608	RGDID:	628817	Length:	592	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	230/621 - (37%)
Similarity:	327/621 - (52%)	Gaps:	92/621 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LMASSGTELD-GL--PHHNR----CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPL 93
            |:|:.|..|: |.  |...|    |:.:.|.:|:.|.||:|.||||:|||.|.||..::.:|:||
  Rat    16 LLATGGAALEIGRFDPERGRGPAPCQAMEIPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPL 80

  Fly    94 VKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPV 156
            |:.||...|:.||||||.|:|| .:..|||.||.:||.||: |..:|:.:||.||::|:|::.|.
  Rat    81 VQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPT 145

  Fly   157 HGG-EDLCV--AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGF--VCPVQLKTPLGMG 216
            ... ..||:  .||.|      |.||                .||:.:|.  |.|...:.|....
  Rat   146 RNDPHALCMEAPENAT------AGPT----------------EPHKGLGMLPVAPRPARPPGDSA 188

  Fly   217 YELKVGG-----------KDLHDCGAPCH---AMFFPERERTVLRYWVGSWAAVCVASCLFTVLT 267
            .....||           :....|...|.   .:|:..|::.....|:..|:|:|..|..|||.|
  Rat   189 PGPGSGGTCDNPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFT 253

  Fly   268 FLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTITQGH 331
            ||::..||:||||.|:||::||.|...|::....|| .||:|.:      :.|.|.    :.|..
  Rat   254 FLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQ------EAGALY----VIQEG 308

  Fly   332 RQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTIS 396
            .:.|.||::|:.||:..||:..||..|...||||||.||||||||.....||:.||.:|||:||.
  Rat   309 LENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIV 373

  Fly   397 VLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKR 461
            ||.|.||.||.|:|:|:|..:|..:|..|:::||..||.:|..|||.||::||.||.:|||.|..
  Rat   374 VLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKTGGTN 438

  Fly   462 TDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPE 526
            |:|||:||::||.||.|:.:||..::.|..||..|.|.|.:       :....||.||..||...
  Rat   439 TEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRL-------RATEQPCTAAAVPGGRR 496

  Fly   527 -------ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYE 584
                   :.|...:||:|...|::||:||.||::||||..:|::...|... ..|.||:|.
  Rat   497 DCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKMA-AGRARAKAC---- 556

  Fly   585 TGPAGGAKST------PLT------PDPEAANESYL 608
            ..|.|..:.|      |..      .||...|.::|
  Rat   557 RTPGGYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	54/124 (44%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	141/334 (42%)
Fzd9	NP_695217.1	CRD_FZ9	36..162	CDD:143572	56/131 (43%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000269\|PubMed:12138115	59..173		53/135 (39%)
		7tmF_FZD9	222..543	CDD:320164	141/337 (42%)
		TM helix 1	232..256	CDD:320164	10/23 (43%)
		TM helix 2	265..286	CDD:320164	9/20 (45%)
		TM helix 3	315..337	CDD:320164	9/21 (43%)
		TM helix 4	358..374	CDD:320164	9/15 (60%)
		TM helix 5	396..419	CDD:320164	8/22 (36%)
		TM helix 6	450..472	CDD:320164	9/21 (43%)
		TM helix 7	504..529	CDD:320164	10/24 (42%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	533..538		2/4 (50%)
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269\|PubMed:12138115	555..592		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810