Protein Alignment fz and Smo

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_036939.1
• Gene: Smo / 25273
• RGDID: 3726
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 159/592 - (26%)
• Similarity: 253/592 - (42%)
• Gaps: 113/592 - (19%)

  Fly    28 PYYRSGGGLMASSGTELDGLP----HHNR---CEPITISIC--KNIPYNMTIMPNLIGHTKQEEA 83
            |..||.||....:.......|    |..|   |||:..::|  ..:||..|..........||||
  Rat    42 PGPRSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEA 106

  Fly    84 GLEVHQFAPLVKI-GCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESAR----VCEKLMKTYNF 143
            ..::..::.|... .|...:|..||::|:|.|. .:|...|.|:||::.|    :.|:     ..
  Rat   107 HSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCE-NDRVELPSRTLCQATRGPCAIVER-----ER 165

  Fly   144 NWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQ 208
            .||:.|.|:  |.|..|                                |..:..:||.|....|
  Rat   166 GWPDFLRCT--PDHFPE--------------------------------GCPNEVQNIKFNSSGQ 196

  Fly   209 LKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLID-S 272
            .:.||......|...:|:..||..|....|.|.|...:..::.::.||.....|||:.||:.| .
  Rat   197 CEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWR 261

  Fly   273 SRFRYPERAIVFLAVCYLVVGCAYVAGL--GAGDSVSCREP----FPPPVKLGRLQMMSTITQGH 331
            :..|||...:.::..|:.|....::|..  ||...:.||..    |..|..
  Rat   262 NSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTS-------------- 312

  Fly   332 RQTTSCTVLFMALYFCCMAAFAWWSCLAFAW---FLAAGLKWGHEAIENKSHLFHLVAWAVPALQ 393
            .:|.||.::|:.:|:..||...|:..|.:||   |.|.|..  ::.:..|:..|||:.|::|.:.
  Rat   313 SETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTT--YQPLSGKTSYFHLLTWSLPFVL 375

  Fly   394 TISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTD 458
            |:::||:|:|:||.:||:||||..:......|::.|:.:.|.:|..||:.|.::||.|::  ...
  Rat   376 TVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS--NHP 438

  Fly   459 G----KRTDKLERLMLRIGFFSGL---FILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPC 516
            |    |...|:...|||:|.|..|   |:|..   ..|.||:::|..||...: ||.     :.|
  Rat   439 GLLSEKAASKINETMLRLGIFGFLAFGFVLIT---FSCHFYDFFNQAEWERSF-RDY-----VLC 494

  Fly   517 PAARAPGSPEARPIFQIFMVKYLCSMLV-----------GVTSSVWLYSSKTMVSWRNFVERLQG 570
            .|....|.|..:||... .:|...|:||           |:..|.|:::..|::.||....||.|
  Rat   495 QANVTIGLPTKKPIPDC-EIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTG 558

  Fly   571 ---KEPR 574
               .||:
  Rat   559 HSDDEPK 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	34/125 (27%)
		Frizzled	237..564	CDD:279827	101/354 (29%)
Smo	NP_036939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..61		5/18 (28%)
		CRD_SMO	70..200	CDD:143560	39/169 (23%)
		Frizzled	225..554	CDD:279827	101/356 (28%)
		Interaction with BBS5 and BBS7. /evidence=ECO:0000250|UniProtKB:P56726	542..573		8/24 (33%)
		Interaction with DLG5. /evidence=ECO:0000250|UniProtKB:P56726	585..597
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..702

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810