DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and FRZB

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001454.2	Gene:	FRZB / 2487	HGNCID:	3959	Length:	325	Species:	Homo sapiens

Alignment Length:	152	Identity:	62/152 - (40%)
Similarity:	88/152 - (57%)	Gaps:	6/152 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GLMASSGTELDGLP--HHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIG 97
            ||:|.:...|..:|  ....|||:.|.:||::|:|||.|||.:.|:.|..|.|.:.||..|:...
Human    15 GLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTH 79

  Fly    98 CSDDLQLFLCSLYVPVCTI--LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGG 159
            ||.||..|||::|.|:|||  ...||.||:|:||.||. ||.::..|..:|||||.|.:.||: .
Human    80 CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVY-D 143

  Fly   160 EDLCVAENTTSSASTAATPTRS 181
            ..:|::.....:|..|..|..|
Human   144 RGVCISPEAIVTADGADFPMDS 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	53/118 (45%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
FRZB	NP_001454.2	CRD_SFRP3	32..157	CDD:143550	53/125 (42%)
		NTR_Sfrp3_like	188..297	CDD:239636
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740