DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz and Frzb

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_035486.1	Gene:	Frzb / 20378	MGIID:	892032	Length:	323	Species:	Mus musculus

Alignment Length:	190	Identity:	68/190 - (35%)
Similarity:	97/190 - (51%)	Gaps:	21/190 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTI- 116
            |||:.|.:||::|:|||.|||.:.|:.|..|.|.:.||..|:...||.||..|||::|.|:|||
Mouse    35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTID 99

  Fly   117 -LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPT 179
             ...||.||:|:||.||. ||.::..|..:|||:|.|.:.||: ...:|::.....:|..|..|.
Mouse   100 FQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVY-DRGVCISPEAIVTADGADFPM 163

  Fly   180 RSVAKVTTRKHQTGVESPHRNIGFVC---PVQL--KTPLGMGYELKVGGKDLHDCGAPCH 234
            .|     :..|..|..|..      |   ||:.  ||.....|...:..| :.:....||
Mouse   164 DS-----STGHCRGASSER------CKCKPVRATQKTYFRNNYNYVIRAK-VKEVKMKCH 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	52/116 (45%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
Frzb	NP_035486.1	CRD_SFRP3	32..157	CDD:143550	52/122 (43%)
		NTR_Sfrp3_like	188..297	CDD:239636	6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740