DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and cfz-2

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_503965.2	Gene:	cfz-2 / 178768	WormBaseID:	WBGene00000478	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	183/553 - (33%)
Similarity:	272/553 - (49%)	Gaps:	55/553 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD 100
            |:.|.|. |.|  ...:||.|||.:||.|.||||..||..||.||||||||||||.|||::||..
Worm    11 LLGSCGA-LFG--KRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQ 72

  Fly   101 DLQLFLCSLYVPVC-TILERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFPVHGGE--- 160
            .|:.|||::|.|:| ...::||.||..||..|| .|..:|..|.|.|||.|.|...|....:
Worm    73 HLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMST 137

  Fly   161 -DLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFV----------CPVQLKTPLG 214
             ::|.|...|..........::..:...:.|....:.|...|..:          |......|..
Worm   138 GNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQ 202

  Fly   215 M--GYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRY 277
            .  ..:.|||  ::.:|...||:....| ..:::..|:..|:..|.....||.|||||::.||:|
Worm   203 FVASEKSKVG--NVTNCAYSCHSPALAE-SHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQY 264

  Fly   278 PERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLF 341
            |||.|..||.|.|:|...::.....| :.::|             ..|..........:.|.|:|
Worm   265 PERPIFMLAFCQLMVAVGFMIRYFVGHEEIAC-------------DSMRIKGADDNSGSLCFVVF 316

  Fly   342 MALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGD 406
            :..||..|||..||..|:..|.|:|..||..|||.:.|..||:|.|.:||:||:.|:....::||
Worm   317 LLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGD 381

  Fly   407 ILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDG---KRTDKLERL 468
            .::|:|:||..|......|::.||.:|..:|.|||:.||.:|:.||..::...   :...|:.:|
Worm   382 PITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQKQHPSLESAHKITQL 446

  Fly   469 MLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSI-PCPAARAPGSPEARPIFQ 532
            |.:||.||.|:.:|::.::..||||         |.||.:.:...: .|...:..|...    ..
Worm   447 MSKIGIFSLLYTIPSLLIICVLFYE---------QNHRSLWEQSQLCSCSPKQTIGDSS----LI 498

  Fly   533 IFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFV 565
            |.::|..|..::|.||..|:.|:||:.||:|.:
Worm   499 ISLIKTCCMCILGWTSGFWVCSTKTLSSWKNAI 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	60/121 (50%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	105/331 (32%)
cfz-2	NP_503965.2	CRD_FZ5_like	24..146	CDD:143565	60/121 (50%)
cfz-2	NP_503965.2	Frizzled	230..532	CDD:279827	105/328 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910