Protein Alignment fz and mom-5

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001300437.1
• Gene: mom-5 / 172856
• WormBaseID: WBGene00003397
• Length: 570
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 219/563 - (38%)
• Similarity: 317/563 - (56%)
• Gaps: 41/563 - (7%)

  Fly    36 LMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSD 100
            |.::|.:.::|.....:||.|||.:|||:.||.|:.|||:|||.|.|||..:.||.||:|:.||:
 Worm    20 LSSTSISSMNGFSTTRKCEHITIPMCKNLDYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSE 84

  Fly   101 DLQLFLCSLYVPVCTILERPIPPCRSLCESAR-VCEKLMKTYNFNWPENLECSKFPVHGGEDLCV 164
            |::||||::|.||||:||:||.|||.||.||: .||.|||.:.|.||:.|:|:||||   .||||
 Worm    85 DIRLFLCTVYAPVCTVLEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPV---TDLCV 146

  Fly   165 AENTTSSASTAATPTRSVAKVT----TRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKD 225
            .:|  ||.|:.:...||...||    |..::. |.||.:     ||..:.|..|..:.|.:....
 Worm   147 GKN--SSESSNSKNYRSSNDVTFGVSTIANEV-VLSPKK-----CPHHMHTTSGSHFSLPLLSGR 203

  Fly   226 LHDCGAPCHA-----MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFL 285
            |.:|...|.|     |.|..|.|.:||.|..:|:..|....|||::|||:|.|||.||.|.|::|
 Worm   204 LPECSLTCEADNQVPMMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYL 268

  Fly   286 AVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMA 350
            |.|||.:...|:.|:...|..:|......|..|        :||| .:...|:.|.:..||..|:
 Worm   269 AFCYLAISTVYMIGVVGEDGFACGTYGSTPTTL--------VTQG-GENVGCSALAVVHYFFFMS 324

  Fly   351 AFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVG 415
            :.|||..|..||||||.||||.|:|...|..||.:.|.|||:.:::||....|:||:.:|:|.||
 Worm   325 SCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVG 389

  Fly   416 QLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMK---TDGKRT-DKLERLMLRIGFFS 476
            .|:..:|..|...|:.:.|::||:.|:.|..|:.|||:.:|   .|.:|. .|||:||||||.|:
 Worm   390 NLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSYIKLQHADVERNISKLEKLMLRIGAFA 454

  Fly   477 GLFILPAVGLLGCLFYEYYNFDEWMIQWHRDIC------KPFSIPCPAARAPGSPE-ARPIFQIF 534
            .::.||.......::|:..|...|:..|....|      :.|....|....|..|: |.|...:|
 Worm   455 IMYSLPTAMNAAIMWYQAVNMPAWLEGWLHHRCVRLQDRELFGFTYPVDDCPMDPKVAAPEIIVF 519

  Fly   535 MVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRA 577
            ::||:..::||:|.::|:.||||:.|:......|..:.|...|
 Worm   520 LLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSRSPTVPA 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	67/116 (58%)
		Frizzled	237..564	CDD:279827	124/337 (37%)
mom-5	NP_001300437.1	CRD_FZ1_like	35..147	CDD:143567	66/114 (58%)
		7tmF_Frizzled_SMO	219..550	CDD:320089	125/339 (37%)
		TM helix 1	228..253	CDD:320089	10/24 (42%)
		TM helix 2	262..282	CDD:320089	8/19 (42%)
		TM helix 3	312..338	CDD:320089	10/25 (40%)
		TM helix 4	355..371	CDD:320089	6/15 (40%)
		TM helix 5	393..422	CDD:320089	8/28 (29%)
		TM helix 6	446..473	CDD:320089	10/26 (38%)
		TM helix 7	512..537	CDD:320089	8/24 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166916
Domainoid	1	1.000	232	1.000	Domainoid score	I1372
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1124
Isobase	1	0.950	-	0	Normalized mean entropy	S3599
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		oto19240
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720