Protein Alignment fz and lin-17

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001021813.1
• Gene: lin-17 / 171832
• WormBaseID: WBGene00003006
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 183/589 - (31%)
• Similarity: 273/589 - (46%)
• Gaps: 97/589 - (16%)

  Fly    52 RCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTI 116
            :|.||.|.:||::|||.|..||.|.|..|.........|.||:|..|...:..|:||::.|:|.|
 Worm    27 KCIPIDIELCKDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPI 91

  Fly   117 -LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCV---AENTTSSASTAA 176
             :.:.:..|:|:||..:. |..:::.:...|||.|.|::||  ...:||:   .:..|...|...
 Worm    92 GMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFP--DPPELCMKPTEDEITGGFSAPR 154

  Fly   177 TPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHD----CGAPC--HA 235
            .||:..:..:::  .||           ||..|.            ..|.||    |...|  :.
 Worm   155 LPTKGSSSSSSK--PTG-----------CPSDLV------------DVDPHDPKSHCAFACQSNV 194

  Fly   236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGL 300
            ||..:.:|.| |.|...:||......||:.|||.||..|||:|||.:.:|::|..:....|:..|
 Worm   195 MFSTDNKRMV-RSWSIWFAAANAGVALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPL 258

  Fly   301 GAGDSV-SCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            .....: ||.       .||..:  |.::.|....:.|...|:..||...||..||...:|..:|
 Worm   259 FIDAPIRSCH-------ALGNGR--SYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYL 314

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            :.|.||..|.||..|...|.|||.:.:|.||.||...||:...|:.:|.||.|::.:|..|:|:|
 Worm   315 SGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVP 379

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            ..|.:.||..|::.||.|:.|.|...:|.|..|.|||:||:::|||..|||||.|..|.|..|::
 Worm   380 RTICIVIGTCFIVGGFASMCRERISFRTRGTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKF 444

  Fly   495 YNFDEWMI--QWHRDICKPFSIPCP----AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLY 553
                  ||  ||.|     .:|.|.    |...|..|:|    :|:|...:.|:..|.:..:|:.
 Worm   445 ------MILTQWTR-----MTIDCKQQSGACHRPTPPQA----EIYMTAVISSLATGFSCLMWVL 494

  Fly   554 SSKTMVSWRNFVERLQGK----------EPRTRAQAYVXYETGPAGGAKSTPLTPDPEAANESYL 608
            |:||:.:|:||:  ..|.          ||.||.             ....|..|.|:.  ..|:
 Worm   495 SAKTVHAWKNFI--FCGMCSSAPVKNPIEPSTRP-------------LLEPPTAPPPQP--PVYM 542

  Fly   609 EFST 612
            :.:|
 Worm   543 QMAT 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	40/119 (34%)
		Frizzled	237..564	CDD:279827	116/333 (35%)
lin-17	NP_001021813.1	CRD_LIN_17	25..144	CDD:143563	40/118 (34%)
		Frizzled	195..506	CDD:279827	118/335 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920