| Sequence 1: | NP_001261836.1 | Gene: | fz / 45307 | FlyBaseID: | FBgn0001085 | Length: | 612 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034376.1 | Gene: | Fzd9 / 14371 | MGIID: | 1313278 | Length: | 592 | Species: | Mus musculus |
| Alignment Length: | 621 | Identity: | 230/621 - (37%) |
|---|---|---|---|
| Similarity: | 327/621 - (52%) | Gaps: | 92/621 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 36 LMASSGTELD-GL--PHHNR----CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPL 93
Fly 94 VKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPV 156
Fly 157 HGG-EDLCV--AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGF--VCPVQLKTPLGMG 216
Fly 217 YELKVGG-----------KDLHDCGAPCH---AMFFPERERTVLRYWVGSWAAVCVASCLFTVLT 267
Fly 268 FLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTITQGH 331
Fly 332 RQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTIS 396
Fly 397 VLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKR 461
Fly 462 TDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPE 526
Fly 527 -------ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYE 584
Fly 585 TGPAGGAKST------PLT------PDPEAANESYL 608 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz | NP_001261836.1 | CRD_FZ1_like | 51..167 | CDD:143567 | 54/124 (44%) |
| Frizzled | 237..564 | CDD:279827 | 141/334 (42%) | ||
| Fzd9 | NP_034376.1 | CRD_FZ9 | 36..162 | CDD:143572 | 56/131 (43%) |
| Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 59..173 | 53/135 (39%) | |||
| 7tmF_FZD9 | 222..543 | CDD:320164 | 141/337 (42%) | ||
| TM helix 1 | 231..256 | CDD:320164 | 10/24 (42%) | ||
| TM helix 2 | 265..286 | CDD:320164 | 9/20 (45%) | ||
| TM helix 3 | 315..341 | CDD:320164 | 10/25 (40%) | ||
| TM helix 4 | 358..374 | CDD:320164 | 9/15 (60%) | ||
| TM helix 5 | 396..426 | CDD:320164 | 12/29 (41%) | ||
| TM helix 6 | 445..472 | CDD:320164 | 12/26 (46%) | ||
| TM helix 7 | 504..529 | CDD:320164 | 10/24 (42%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 533..538 | 2/4 (50%) | |||
| Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 555..592 | 8/40 (20%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.810 | |||||