Protein Alignment fz and Fzd8

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_032084.2
• Gene: Fzd8 / 14370
• MGIID: 108460
• Length: 685
• Species: Mus musculus
• Alignment Length: 628
• Identity: 240/628 - (38%)
• Similarity: 329/628 - (52%)
• Gaps: 103/628 - (16%)

  Fly    22 SPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLE 86
            |.|.|....:...|..|:|..||       .|:.||:.:||.|.||.|.|||...|..|:|||||
Mouse    11 SLLAALAVLQRSSGAAAASAKEL-------ACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLE 68

  Fly    87 VHQFAPLVKIGCSDDLQLFLCSLYVPVCTILE---RPIPPCRSLCESARV-CEKLMKTYNFNWPE 147
            ||||.|||:|.||.||:.||||:|.|:|  ||   :|:|||||:||.|:. |..||:.|.|.||:
Mouse    69 VHQFWPLVEIQCSPDLKFFLCSMYTPIC--LEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPD 131

  Fly   148 NLECSKFPVHGGED-LCVAENTTSSASTAATPTRSVAKVTTRKHQ----------TGVESPHRN- 200
            .:.|.:.|..|..| ||:..|.|...:.|.:|.|.:........|          .|...|||.
Mouse   132 RMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGG 196

  Fly   201 ----------------------IGFVCP----VQLKTPL--------GMGYELKVGGKDLHDCGA 231
                                  .|...|    .|.:.|:        .:...:|.|  .:.:|..
Mouse   197 SSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTG--QIANCAL 259

  Fly   232 PCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAY 296
            |||..||.:.||....:|:|.|:.:|..|...||.|||||..||:||||.|:||:.|||.|...|
Mouse   260 PCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGY 324

  Fly   297 VAGLGAG-DSVSCREPFP------------------------PPVKLGRLQMMSTITQGHRQTTS 336
            :..|.|| :.|:|....|                        .|...|..:.:..:.|..|..|:
Mouse   325 LVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETT 389

  Fly   337 ----CTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISV 397
                |||:|:.:||..||:..||..|:..||||||:|||:|||...|..|||.||.||::::|:|
Mouse   390 GPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAV 454

  Fly   398 LALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDG--K 460
            |||:.|:||.::|:|:||.....:|..|::.||.|||.||.:||||||:||||||:|:|..|  .
Mouse   455 LALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPT 519

  Fly   461 RTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSP 525
            :|.|||:||:|:|.|:.|:.:||..::.|||||.:|...|....:          ||..|.....
Mouse   520 KTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHN----------CPCLRDLQPD 574

  Fly   526 EA-RPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVER 567
            :| ||.:.:||:||...::||:||.||::|.||:.|||....|
Mouse   575 QARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTR 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	62/120 (52%)
		7tmF_FZD1_insect	236..568	CDD:320376	150/364 (41%)
		TM helix 1	245..270	CDD:320376	9/24 (38%)
		TM helix 2	279..300	CDD:320376	10/20 (50%)
		TM helix 3	338..364	CDD:320376	11/25 (44%)
		TM helix 4	381..397	CDD:320376	8/15 (53%)
		TM helix 5	419..448	CDD:320376	15/28 (54%)
		TM helix 6	468..495	CDD:320376	13/26 (50%)
		TM helix 7	527..552	CDD:320376	12/25 (48%)
Fzd8	NP_032084.2	CRD_FZ8	31..155	CDD:143570	65/132 (49%)
		Wnt-binding	95..100		3/6 (50%)
		Wnt-binding	147..152		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..223		9/67 (13%)
		7tmF_FZD8	264..616	CDD:320378	149/361 (41%)
		TM helix 1	273..298	CDD:320378	9/24 (38%)
		TM helix 2	307..328	CDD:320378	10/20 (50%)
		TM helix 3	395..417	CDD:320378	10/21 (48%)
		TM helix 4	438..454	CDD:320378	8/15 (53%)
		TM helix 5	476..499	CDD:320378	10/22 (45%)
		TM helix 6	529..554	CDD:320378	11/24 (46%)
		TM helix 7	577..602	CDD:320378	11/24 (46%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	606..611		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	631..656
		PDZ-binding	683..685