DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz and Fzd7

DIOPT Version :10

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_032083.3 Gene:Fzd7 / 14369 MGIID:108570 Length:572 Species:Mus musculus


Alignment Length:562 Identity:272/562 - (48%)
Similarity:351/562 - (62%) Gaps:42/562 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PLD--ASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGL 85
            |.|  |.||:          |.:...:|.|..|:||:|.:|.:|.||.||:|||:|||.||:|||
Mouse    27 PTDTRAQPYH----------GEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGL 81

  Fly    86 EVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENL 149
            |||||.||||:.||.:|:.||||:|.||||:|::.|||||||||.||. ||.||..:.|.|||.|
Mouse    82 EVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERL 146

  Fly   150 ECSKFPVHGGEDLCVAENTT-SSASTAATPTRSVAKVTTRKHQTGVESPHRNIG-----FVCPVQ 208
            .|..|||||..::||.:||: .|.....:||................||....|     |.||.|
Mouse   147 RCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQ 211

  Fly   209 LKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLT 267
            ||.|..:||.. :|.:   ||||||.      .|:|.|.||...|.|||.|:.:|.||.||||||
Mouse   212 LKVPPYLGYRF-LGER---DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLT 272

  Fly   268 FLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHR 332
            :|:|..||.||||.|:||:.||.:|..|:|||....|...|.|.|..       ....|:.||.:
Mouse   273 YLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSD-------DGYRTVAQGTK 330

  Fly   333 QTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISV 397
            : ..||:|||.|||..||:..||..|:..||||||:||||||||..|..|||.||||||::||::
Mouse   331 K-EGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITI 394

  Fly   398 LALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRT 462
            ||:.:|:||:|||||:||.....:|..|::.||.:||.||..||||||:|||||||:||.||.:|
Mouse   395 LAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT 459

  Fly   463 DKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAAR-APGSPE 526
            :|||:||:|||.||.|:.:||..:|.|.|||....:.|...|....||.:::|||... :|.||:
Mouse   460 EKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPD 524

  Fly   527 ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL 568
                |.:||:|||.:|:||:|:..|::|.||:.|||.|..||
Mouse   525 ----FTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 71/116 (61%)
7tmF_FZD1_insect 236..568 CDD:320376 167/332 (50%)
TM helix 1 245..270 CDD:320376 14/24 (58%)
TM helix 2 279..300 CDD:320376 11/20 (55%)
TM helix 3 338..364 CDD:320376 13/25 (52%)
TM helix 4 381..397 CDD:320376 11/15 (73%)
TM helix 5 419..448 CDD:320376 14/28 (50%)
TM helix 6 468..495 CDD:320376 15/26 (58%)
TM helix 7 527..552 CDD:320376 10/24 (42%)
Fzd7NP_032083.3 CRD_FZ7 45..169 CDD:143575 74/123 (60%)
7tmF_FZD7 241..571 CDD:320374 169/334 (51%)
TM helix 1 250..275 CDD:320374 14/24 (58%)
TM helix 2 284..305 CDD:320374 11/20 (55%)
TM helix 3 335..361 CDD:320374 13/25 (52%)
TM helix 4 378..394 CDD:320374 11/15 (73%)
TM helix 5 416..445 CDD:320374 14/28 (50%)
TM helix 6 465..492 CDD:320374 15/26 (58%)
TM helix 7 521..546 CDD:320374 12/28 (43%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 550..555 2/4 (50%)
PDZ-binding 570..572
Blue background indicates that the domain is not in the aligned region.

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