DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and Fzd5

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001036124.1	Gene:	Fzd5 / 14367	MGIID:	108571	Length:	585	Species:	Mus musculus

Alignment Length:	592	Identity:	239/592 - (40%)
Similarity:	331/592 - (55%)	Gaps:	74/592 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC-TI 116
            |:.||:.:|:.|.||:|.|||...|..|:|||||||||.|||:|.||.||:.||||:|.|:| ..
Mouse    33 CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPD 97

  Fly   117 LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGG--EDLCVAENTTSSASTAATP 178
            ..:|:|||||:||.|:. |..||:.|.|.|||.:.|.:.||.||  |.||:..|  .|.:|.|:|
Mouse    98 YHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYN--RSEATTASP 160

  Fly   179 TRSVAKVT----TRKHQTGVESPHRNIGFVC-------PVQLKTPLGMGYELKVGGKDLHDCGAP 232
            ....||.|    .....:|.|.|..... ||       |: ||....:..:::.|  .:.:|..|
Mouse   161 KSFPAKPTLPGPPGAPSSGGECPSGGPS-VCTCREPFVPI-LKESHPLYNKVRTG--QVPNCAVP 221

  Fly   233 CHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYV 297
            |:...|...|||...:|:|.|:.:|..|...||.|||||..|||||||.|:||:.|||.|...::
Mouse   222 CYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFL 286

  Fly   298 AGLGAGD-SVSC-REPFPPPVKLGRLQMMSTITQGHRQTTS---CTVLFMALYFCCMAAFAWWSC 357
            ..|..|. ||:| ||.                :..|.:||.   |||:|:.:||..||:..||..
Mouse   287 VRLVVGHASVACSREH----------------SHIHYETTGPALCTVVFLLVYFFGMASSIWWVI 335

  Fly   358 LAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSL 422
            |:..||||||:|||:|||...:..|||.||.:|::::|:.|||:.|:||.::|:|:||..:.:||
Mouse   336 LSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSL 400

  Fly   423 GAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLL 487
            ..|::.||.:||.:|.|||||||:||||||:|:|..|.:|||||:||:|||.|:.|:.:||..::
Mouse   401 RGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVV 465

  Fly   488 GCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWL 552
            .|..||.:..:.|.        ...:..||...| |.|.|:|.:.:.|:||...::||:||.||:
Mouse   466 ACYLYEQHYRESWE--------AALTCACPGPDA-GQPRAKPEYWVLMLKYFMCLVVGITSGVWI 521

  Fly   553 YSSKTMVSWRNFVERLQGKEPR-------------TRAQAYVXYETGPAGGAKSTPLTPDPEAAN 604
            :|.||:.|||.|..|......|             ..|.|.:...|||          |.|.||.
Mouse   522 WSGKTLESWRRFTSRCCCSSRRGHKSGGAMAAGDYAEASAALTGRTGP----------PGPTAAY 576

  Fly   605 ESYLEFS 611
            ...:..|
Mouse   577 HKQVSLS 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	62/117 (53%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	144/331 (44%)
Fzd5	NP_001036124.1	CRD_FZ5	29..156	CDD:143569	64/124 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..182		7/25 (28%)
		7tm_GPCRs	225..535	CDD:333717	145/334 (43%)
		TM helix 1	235..259	CDD:320095	9/23 (39%)
		TM helix 2	268..289	CDD:320095	9/20 (45%)
		TM helix 3	316..338	CDD:320095	10/21 (48%)
		TM helix 4	359..375	CDD:320095	7/15 (47%)
		TM helix 5	397..420	CDD:320095	10/22 (45%)
		TM helix 6	448..473	CDD:320095	10/24 (42%)
		TM helix 7	496..521	CDD:320095	10/24 (42%)
		PDZ-binding. /evidence=ECO:0000250	582..584		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810