DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and Fzd3

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_067433.1 Gene:Fzd3 / 14365 MGIID:108476 Length:666 Species:Mus musculus


Alignment Length:533 Identity:218/533 - (40%)
Similarity:299/533 - (56%) Gaps:55/533 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:.:|:::|||.|.||||:.|..|:.|.|.:..|.|:|.:.||.|.:.|||:||.|:|...
Mouse    28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEY 92

  Fly   118 ERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFP---------VHGGEDLCVAENTTSSA 172
            .|...|||.||:.| ..|.|||:.:...|||::|||:||         |    ||.:..:.|..|
Mouse    93 GRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLV----DLNLVGDPTEGA 153

  Fly   173 STAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLH--DCGAPCHA 235
            ..|.                     .|:.||.||.:||....:||..      ||  ||..||..
Mouse   154 PVAV---------------------QRDYGFWCPRELKIDPDLGYSF------LHVRDCSPPCPN 191

  Fly   236 MFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGL 300
            |:|...|.:..||::|..:.:|:::.|||.||||||.:|||||||.|:|.||||::|...:..|.
Mouse   192 MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF 256

  Fly   301 GAGDSVSCREPFPPPVKLGRLQMMSTITQG-HRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFL 364
            ...|.|:|....|...|      .||:||| |.:  :||:|||.|||..||...||..|...|||
Mouse   257 LLEDRVACNASSPAQYK------ASTVTQGSHNK--ACTMLFMVLYFFTMAGSVWWVILTITWFL 313

  Fly   365 AAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILP 429
            ||..|||.||||.|:.|||..||.:|...||.:||:.|:|||.:|||||||..|..:|..|::.|
Mouse   314 AAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAP 378

  Fly   430 LCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEY 494
            ||:|:.:|...||||.|||.|:|..:..:.:..|||.:.|:|||.||.|:::|.:.::||.|||.
Mouse   379 LCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQ 443

  Fly   495 YNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMV 559
            .....|...|.::.|:.:.||||......|   ||...:|::|||.:::||:.|..|:.|.||..
Mouse   444 AYRGIWETTWIQERCREYHIPCPYQVTQMS---RPDLILFLMKYLMALIVGIPSIFWVGSKKTCF 505

  Fly   560 SWRNFVERLQGKE 572
            .|.:|....:.||
Mouse   506 EWASFFHGRRKKE 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 53/123 (43%)
Frizzled 237..564 CDD:279827 143/327 (44%)
Fzd3NP_067433.1 CRD_FZ3 24..150 CDD:143558 53/125 (42%)
Frizzled 193..512 CDD:279827 144/329 (44%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 502..507 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..666
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D167933at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11309
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.920

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