Protein Alignment fz and LOC1272095

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: XP_061506295.1
• Gene: LOC1272095 / 1272095
• VectorBaseID: AGAMI1_008925
• Length: 814
• Species: Anopheles gambiae
• Alignment Length: 707
• Identity: 159/707 - (22%)
• Similarity: 251/707 - (35%)
• Gaps: 222/707 - (31%)

  Fly    39 SSGTELDGLPHHNRCEPITISICKNIPYNMTI--------------MPNLIGHTKQEEAG----- 84
            ::|.||       |||.|.:..|:|:.|:|||              :|...|......||
Mosquito    17 AAGEEL-------RCERIAVGACQNLVYDMTIASAPETALQYLSSSVPVPGGGVNSTAAGSVRTW 74

  Fly    85 LE----VHQFAPLVKIGCSDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESARV-C------EKL 137
            |:    :....|::..|||.......||...|:|: ...||:.|||||||..|. |      .||
Mosquito    75 LDAERLITSLRPVIDSGCSKQALFLFCSSLFPLCSPTAPRPVHPCRSLCEQVRKDCFSDPAHSKL 139

  Fly   138 MKTYNFNWPENLECSKFPVHGGEDLC--VAENTTSS-------------------ASTAATPT-- 179
                   ||..|:|...|.....:||  |..:.|.|                   ..||.||:
Mosquito   140 -------WPAYLDCRALPQPEKHELCMQVPSDATGSIKQRAGPSGPTYHLPVATTGGTAGTPSPT 197

  Fly   180 ------RSVAKVTTRKHQTGVESPHRNIGFVCPVQLKT-PLGMG--------------------Y 217
                  .||.|..:..:.|.:...|..:.........| |.|.|                    .
Mosquito   198 TTHDSVESVVKGWSISNLTSLLQQHAAVAAAAAAAAATVPAGAGGVAHTVIGGGGGSGGVGAGSS 262

  Fly   218 ELKVGGKDLHDCGA----------------------------PCHAMF----------------- 237
            ....||:.|.| ||                            ||.|.:
Mosquito   263 TATAGGQRLVD-GASWTDRINSLLLPNGPLPVDGAGGPAPRSPCPANYSLEYDRCVPRCGPTIDA 326

  Fly   238 -FPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLG 301
             :.:|::.::..|....:|||....|.::::|...:|:..||:|.|:|:.:||.::|..|:.
Mosquito   327 LYSQRQKELVELWTLVLSAVCFIFTLTSLVSFWAKASKLEYPDRPILFMTLCYNLLGLCYLE--- 388

  Fly   302 AGDSVSCREPFPPPVKL-GRLQMMSTITQGHRQ--------------TTSCTVLFMALYFCCMAA 351
                   |.....|.:| ..:::|.....||..              |:.|...::..::..::|
Mosquito   389 -------RTILHSPRRLEAAVELMLLDAPGHHPSAATATHLRSDCTITSQCLAYYILKHYLLLSA 446

  Fly   352 FAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQ 416
            ..||......|:|:...:|..||:|.||.|||::||.||....|..|....::...|:|.|
Mosquito   447 STWWLIFGLCWYLSTAKQWSCEALERKSGLFHVLAWVVPFAAPIGALLRGHIQRFELTGFC---- 507

  Fly   417 LDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFIL 481
                :...|..||:.:.|.:|...:.....:|.|:|...   .:|...|.|:..|:..|:..::|
Mosquito   508 ----NARGFTELPVLLLLLLGTALVSCALAALARLRHCW---NQRAPHLGRVFGRVLLFAVCYLL 565

  Fly   482 PAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGS---PEARPIFQIF--MVKYLCS 541
            ||:....|:..|..:.:              ..||||...||.   ...:|.|.:.  :::...:
Mosquito   566 PALSATVCMMLERVDHE--------------LEPCPAGGEPGDGCVHRVQPHFSLLPTVLRLALT 616

  Fly   542 MLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYETGPAGGAKSTPLTP 598
            :|.|.:..|||:|                ::|...       |.||  |.|..|..|
Mosquito   617 LLGGGSVGVWLWS----------------RQPSDT-------ELGP--GGKKGPAQP 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	44/148 (30%)
		7tmF_FZD1_insect	236..568	CDD:320376	80/369 (22%)
		TM helix 1	245..270	CDD:320376	6/24 (25%)
		TM helix 2	279..300	CDD:320376	7/20 (35%)
		TM helix 3	338..364	CDD:320376	4/25 (16%)
		TM helix 4	381..397	CDD:320376	8/15 (53%)
		TM helix 5	419..448	CDD:320376	5/28 (18%)
		TM helix 6	468..495	CDD:320376	7/26 (27%)
		TM helix 7	527..552	CDD:320376	5/26 (19%)
LOC1272095	XP_061506295.1	None