DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and FZD10

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_009128.1 Gene:FZD10 / 11211 HGNCID:4039 Length:581 Species:Homo sapiens


Alignment Length:587 Identity:230/587 - (39%)
Similarity:329/587 - (56%) Gaps:77/587 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 GGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGC 98
            |...|.|..::: .|...:|:||.|.:||:|.||||.||||:||..|.||.:::|:|||||:.||
Human    16 GSCAAISSMDME-RPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGC 79

  Fly    99 SDDLQLFLCSLYVPVCT-ILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGED 161
            ...|:.||||||.|:|| .:..|||.||.:||.||: |..:|:.:||.||::|:|.|.|.....:
Human    80 HGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPN 144

  Fly   162 -LCV-AENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPV--QLKTPLGMGYELKVG 222
             ||: |.|                        .|.:.|.|..|...|:  ..:......:.||.|
Human   145 YLCMEAPN------------------------NGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDG 185

  Fly   223 GKDLHDCGAP-----------CHAM-------FFPERERTVLRYWVGSWAAVCVASCLFTVLTFL 269
            |.....|..|           |..:       ::...::.....|:..||.:|..|..|||||||
Human   186 GPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFL 250

  Fly   270 IDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSC-REPFPPPVKLGRLQMMSTITQGHR 332
            ||.:|||||||.|:||::||.|....|:..|.|| :|::| |:.       |:|.    :.|...
Human   251 IDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDS-------GQLY----VIQEGL 304

  Fly   333 QTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISV 397
            ::|.||::|:.||:..||:..||..|...||||||.||||||||..|..|||.|||:||::||.:
Human   305 ESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILI 369

  Fly   398 LALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRT 462
            |.:.:|.||.|:|||:||.:|.::|..|:::||..||.||..|:|:||::||.||.||||.|:.|
Human   370 LVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENT 434

  Fly   463 DKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICK----PFSIPCPAARAPG 523
            ||||:||:|||.||.|:.:||..::.|.|||..|.|.|.|...:..||    ..::.|..|    
Human   435 DKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMA---- 495

  Fly   524 SPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYETGPA 588
              .:.|..:|||||....::||:||.:|:::|||:.||:....|...|:.|.:..:.:.     :
Human   496 --ASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVIT-----S 553

  Fly   589 GG 590
            ||
Human   554 GG 555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 60/119 (50%)
Frizzled 237..564 CDD:279827 148/332 (45%)
FZD10NP_009128.1 CRD_FZ10 30..156 CDD:143571 62/149 (42%)
7tmF_FZD10 217..535 CDD:320165 148/334 (44%)
TM helix 1 226..251 CDD:320165 11/24 (46%)
TM helix 2 260..281 CDD:320165 9/20 (45%)
TM helix 3 310..336 CDD:320165 10/25 (40%)
TM helix 4 353..369 CDD:320165 10/15 (67%)
TM helix 5 391..420 CDD:320165 12/28 (43%)
TM helix 6 440..467 CDD:320165 14/26 (54%)
TM helix 7 497..522 CDD:320165 10/24 (42%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 526..531 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 560..581
PDZ-binding 579..581
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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