Protein Alignment fz and fzd4

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: XP_002936589.1
• Gene: fzd4 / 100497693
• XenbaseID: XB-GENE-478210
• Length: 523
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 214/560 - (38%)
• Similarity: 303/560 - (54%)
• Gaps: 88/560 - (15%)

  Fly    35 GLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCS 99
            |.:|..|.|     ...||:||.||:|:|:.||:|.||||:||..|.:|.|::..|.||::.|||
 Frog    18 GHIAGFGDE-----EERRCDPIRISMCQNLGYNVTKMPNLVGHELQADAELQLTTFTPLIQYGCS 77

  Fly   100 DDLQLFLCSLYVPVCT-ILERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGED- 161
            ..||.||||:|||:|| .:..||.||..:|.|. |.||.::|.:.|.|||:|.|||||.....:
 Frog    78 SQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNH 142

  Fly   162 LCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGG--- 223
            :|                              :|.|..:   ..||..|||:..|.:....|
 Frog   143 MC------------------------------MEGPGDD---EVPVHSKTPVLPGEDCNSFGPNS 174

  Fly   224 ------KDLHDCGAPC--HAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPER 280
                  |...:|...|  .:..:....:.....|:..||::|..|..|||||||||||||.||||
 Frog   175 DQYTWVKRSMNCVLKCGYDSGLYSRLSKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFCYPER 239

  Fly   281 AIVFLAVCYLVVGCAYVAGLGAG-DSVSCR-EPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMA 343
            .|:||::||.:...||:..|..| :.:||. |....||          :.|...:.|.|.::|:.
 Frog   240 PIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPV----------LIQEGLKNTGCAIIFLL 294

  Fly   344 LYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDIL 408
            :||..||:..||..|...|||||||||||||||..|..||:.|||:||::||.:|.:..|:.|.|
 Frog   295 MYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADEL 359

  Fly   409 SGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIG 473
            :|:|:||..:..:|..|::.||..||.||.||:.||.::||:||:.::.||.:||||||||::||
 Frog   360 TGLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIG 424

  Fly   474 FFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKY 538
            .||.|:.:||..::.|.|||..|::.:..                 .|..|..|..:..|||
 Frog   425 VFSVLYTVPATCVIACYFYEISNWNVFRY-----------------TADDSNMAVEMLNIFM--- 469

  Fly   539 LCSMLVGVTSSVWLYSSKTMVSWRNFVERL--QGKEPRTR 576
              |:|||:||.:|::|:||:.:|:....||  .||..|.:
 Frog   470 --SLLVGITSGMWIWSAKTLHTWQKCTNRLVNSGKVKRKK 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	58/118 (49%)
		Frizzled	237..564	CDD:279827	135/328 (41%)
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	60/157 (38%)
		7tmF_FZD4	195..495	CDD:320166	135/331 (41%)
		TM helix 1	204..229	CDD:320166	11/24 (46%)
		TM helix 2	238..259	CDD:320166	9/20 (45%)
		TM helix 3	289..315	CDD:320166	9/25 (36%)
		TM helix 4	332..348	CDD:320166	9/15 (60%)
		TM helix 5	370..399	CDD:320166	12/28 (43%)
		TM helix 6	419..446	CDD:320166	13/26 (50%)
		TM helix 7	456..481	CDD:320166	11/29 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910