Protein Alignment fz and fzd6

DIOPT Version :10

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001238809.2
• Gene: fzd6 / 100490861
• XenbaseID: XB-GENE-478813
• Length: 724
• Species: Xenopus tropicalis
• Alignment Length: 525
• Identity: 215/525 - (40%)
• Similarity: 290/525 - (55%)
• Gaps: 37/525 - (7%)

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:..|..:.||||..|||:.|..|:.|.|.:..|.||:.:.||.::..|||..:||.||..
 Frog    43 CEPITVPRCTGMNYNMTFFPNLLEHYDQDIAALRMEPFLPLLNLHCSPEVHTFLCRAFVPECTEP 107

  Fly   118 ERPIPPCRSLCESARV---CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPT 179
            :....|||||||  ||   |:.|::|:...||..|||.:.     .|   ..|:.|.........
 Frog   108 KHITMPCRSLCE--RVYSDCKNLIETFGITWPAELECDRM-----RD---CNNSQSKGGGGPDDP 162

  Fly   180 RSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERT 244
            ....     :|.   |..||:..|.||..|||..|.|:  |..|.|  .|..||..|:|.:.:..
 Frog   163 HDAL-----RHP---EQVHRDFKFWCPQHLKTSQGSGF--KFLGVD--RCAPPCPNMYFKKVDMD 215

  Fly   245 VLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCR 309
            ..:|::|..:.:|:...||||||||||..|||||||.|:|.:|||.:|...||.|...|:|:.|.
 Frog   216 FAKYFIGVISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYSVCYSMVSLMYVIGFLMGNSIVCN 280

  Fly   310 EPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEA 374
            |      :........|:..| .|..:||::||.||||.||...||..|...||||||.||..||
 Frog   281 E------REENFASGDTVVLG-SQHKACTIIFMLLYFCTMAGTIWWVMLTITWFLAAGRKWSCEA 338

  Fly   375 IENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGAL 439
            ||.||..||.|||.:|.:.||.:||:.|||||.:|||||||..|......|::||||:.:.||..
 Frog   339 IEQKSLWFHGVAWGIPGILTIILLAMNKVEGDNISGVCFVGLYDQEVSIYFVLLPLCLCVFIGLS 403

  Fly   440 FLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQW 504
            .||||.|||..:|.|::.|.:...||::.|:|||.|||.:::|.|.||||..||......|.:.|
 Frog   404 LLLAGIISLNNVRQVIQHDERNQQKLKKFMIRIGVFSGTYLVPLVILLGCYVYEQVYRSSWEMTW 468

  Fly   505 HRDICKPFSIPCP-AARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL 568
            ..|.|:.:.|||| ..:.|    |||...:|:.||:.:::||:::..|:.|.||...|.||..|.
 Frog   469 VSDNCQDYHIPCPFQLKNP----ARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVNFFNRS 529

  Fly   569 QGKEP 573
            :.::|
 Frog   530 RKQDP 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	47/116 (41%)
		7tmF_FZD1_insect	236..568	CDD:320376	146/332 (44%)
		TM helix 1	245..270	CDD:320376	10/24 (42%)
		TM helix 2	279..300	CDD:320376	10/20 (50%)
		TM helix 3	338..364	CDD:320376	13/25 (52%)
		TM helix 4	381..397	CDD:320376	8/15 (53%)
		TM helix 5	419..448	CDD:320376	12/28 (43%)
		TM helix 6	468..495	CDD:320376	15/26 (58%)
		TM helix 7	527..552	CDD:320376	8/24 (33%)
fzd6	NP_001238809.2	CRD_FZ6	39..172	CDD:143559	51/146 (35%)
		7tmF_FZD6	207..527	CDD:320160	146/330 (44%)
		TM helix 1	216..241	CDD:320160	10/24 (42%)
		TM helix 2	250..271	CDD:320160	10/20 (50%)
		TM helix 3	302..328	CDD:320160	13/25 (52%)
		TM helix 4	345..361	CDD:320160	8/15 (53%)
		TM helix 5	383..412	CDD:320160	12/28 (43%)
		TM helix 6	432..459	CDD:320160	15/26 (58%)
		TM helix 7	488..513	CDD:320160	8/24 (33%)