Protein Alignment fz and fzd5

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: XP_004917802.1
• Gene: fzd5 / 100488110
• XenbaseID: XB-GENE-479707
• Length: 559
• Species: Xenopus tropicalis
• Alignment Length: 569
• Identity: 230/569 - (40%)
• Similarity: 324/569 - (56%)
• Gaps: 68/569 - (11%)

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC-TI 116
            |:.||:.:||.|.||.|.|||...|..|:|||:|||||.|||.|.||.||:.||||:|.|:| ..
 Frog    33 CQEITVPMCKGIGYNHTYMPNQFNHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLCSMYTPICLPD 97

  Fly   117 LERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGED-LCVAENTTSSASTAATPT 179
            ..:|:|||||:||.|:. |..||:.|.|.|||.:.|.:.|.||..| ||:..|.|.: :|...||
 Frog    98 YRKPLPPCRSVCERAKAGCSPLMRKYGFAWPERMNCDRLPEHGDPDTLCMDYNWTET-TTTPPPT 161

  Fly   180 RSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTP-LGMGYE-------LKVGGKDLHDCGAPCHAM 236
                      |...|::|..:...||  :.:.| |.:..|       :|.|  .:.:|..||...
 Frog   162 ----------HPPKVKTPSSDCDGVC--KCREPFLSITRESHPLYNRIKTG--QVPNCAMPCFQP 212

  Fly   237 FFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLG 301
            :|.:.|:|...:|:|.|:.:|..|...||.|||||..|||||||.|:||:.|||.|...|:..|.
 Frog   213 YFTQDEKTFATFWIGLWSILCFISTFTTVATFLIDMERFRYPERPIIFLSACYLFVSIGYIVRLI 277

  Fly   302 AG-DSVSCREPFPPPVKLGRLQMMSTITQGHRQTTS---CTVLFMALYFCCMAAFAWWSCLAFAW 362
            .| ::|:|.:                 ...|.:||.   |||:|:.:||..||:..||..|.|.|
 Frog   278 VGHENVACNK-----------------DHIHYETTGPALCTVVFLLIYFFGMASSIWWVILTFTW 325

  Fly   363 FLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLI 427
            |||||:|||:|||.:.|..||:.||.:|::::|:||||:.|:||.::|:||||..:..:|..|::
 Frog   326 FLAAGMKWGNEAIASYSQYFHMAAWLIPSVKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVL 390

  Fly   428 LPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFY 492
            .||.:||..|.:||||||:||||||:|:|..|.:|||||:||:|||.||.|:.:||..::.|..|
 Frog   391 APLVVYLFTGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACYIY 455

  Fly   493 EYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKT 557
            |.:..:.|.        |..:..||..:    ...||.:.:||:||...::||:||.||::|.||
 Frog   456 EQHYREHWE--------KAHNCSCPGDK----KRYRPDYAVFMLKYFMCLVVGITSGVWIWSGKT 508

  Fly   558 MVSWRNFVERLQGKEPRTRAQAY------VXYETGPAGGA---KSTPLT 597
            :.||:.|..|.........|.||      :...||.:...   |..||:
 Frog   509 LESWKRFTGRCCRNSKPINASAYSEASRALTARTGLSSSTLHHKQVPLS 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	61/116 (53%)
		Frizzled	237..564	CDD:279827	141/330 (43%)
fzd5	XP_004917802.1	CRD_FZ5	29..153	CDD:143569	62/119 (52%)
		7tmF_FZD5	212..517	CDD:320377	142/333 (43%)
		TM helix 1	221..246	CDD:320377	9/24 (38%)
		TM helix 2	255..276	CDD:320377	10/20 (50%)
		TM helix 3	301..327	CDD:320377	12/25 (48%)
		TM helix 4	344..360	CDD:320377	6/15 (40%)
		TM helix 5	382..411	CDD:320377	13/28 (46%)
		TM helix 6	431..458	CDD:320377	13/26 (50%)
		TM helix 7	478..503	CDD:320377	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910