DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz and Fzd7

DIOPT Version :9

Sequence 1:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001258114.1	Gene:	Fzd7 / 100360552	RGDID:	2321905	Length:	572	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	272/562 - (48%)
Similarity:	351/562 - (62%)	Gaps:	42/562 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PLD--ASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGL 85
            |.|  |.||:          |.:...:|.|..|:||:|.:|.:|.||.||:|||:|||.||:|||
  Rat    27 PTDTGAQPYH----------GEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGL 81

  Fly    86 EVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV-CEKLMKTYNFNWPENL 149
            |||||.||||:.||.:|:.||||:|.||||:|::.|||||||||.||. ||.||..:.|.|||.|
  Rat    82 EVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERL 146

  Fly   150 ECSKFPVHGGEDLCVAENTT-SSASTAATPTRSVAKVTTRKHQTGVESPHRNIG-----FVCPVQ 208
            .|..|||||..::||.:||: .|.....:||................||....|     |.||.|
  Rat   147 RCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRWSFPFSCPRQ 211

  Fly   209 LKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLT 267
            ||.|..:||.. :|.:   ||||||.      .|:|.|.||...|.|||.|:.:|.||.||||||
  Rat   212 LKVPPYLGYRF-LGER---DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLT 272

  Fly   268 FLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHR 332
            :|:|..||.||||.|:||:.||.:|..|:|||....|...|.|.|..       ....|:.||.:
  Rat   273 YLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSD-------DGYRTVAQGTK 330

  Fly   333 QTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISV 397
            : ..||:|||.|||..||:..||..|:..||||||:||||||||..|..|||.||||||::||::
  Rat   331 K-EGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITI 394

  Fly   398 LALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRT 462
            ||:.:|:||:|||||:||.....:|..|::.||.:||.||..||||||:|||||||:||.||.:|
  Rat   395 LAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT 459

  Fly   463 DKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAAR-APGSPE 526
            :|||:||:|||.||.|:.:||..:|.|.|||....:.|...|....||.:::|||... :|.||:
  Rat   460 EKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPD 524

  Fly   527 ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERL 568
                |.:||:|||.:|:||:|:..|::|.||:.|||.|..||
  Rat   525 ----FTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	71/116 (61%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	165/327 (50%)
Fzd7	NP_001258114.1	CRD_FZ7	45..169	CDD:143575	74/123 (60%)
		7tmF_FZD7	241..571	CDD:320374	169/334 (51%)
		TM helix 1	251..275	CDD:320374	14/23 (61%)
		TM helix 2	284..305	CDD:320374	11/20 (55%)
		TM helix 3	335..357	CDD:320374	12/21 (57%)
		TM helix 4	378..394	CDD:320374	11/15 (73%)
		TM helix 5	416..439	CDD:320374	9/22 (41%)
		TM helix 6	470..492	CDD:320374	11/21 (52%)
		TM helix 7	521..546	CDD:320374	12/28 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3954
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1169
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm45657
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840