DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz and fzd8

DIOPT Version :9

Sequence 1:NP_001261836.1 Gene:fz / 45307 FlyBaseID:FBgn0001085 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001090860.2 Gene:fzd8 / 100038274 XenbaseID:XB-GENE-480800 Length:580 Species:Xenopus tropicalis


Alignment Length:580 Identity:244/580 - (42%)
Similarity:335/580 - (57%) Gaps:65/580 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 GLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCS 99
            |...::..||.       |:.||:.:||:|.||.|.|||...|..|:|||:|||||.|||.|.||
 Frog    16 GSQCAAAKELS-------CQEITVPLCKDIGYNYTYMPNQFNHDTQDEAGMEVHQFWPLVVIHCS 73

  Fly   100 DDLQLFLCSLYVPVCTILE---RPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGGE 160
            .||:.||||:|.|:|  ||   :|:|||||:||.||. |..||:.|.|.||:.:.|.:.|..|..
 Frog    74 PDLKFFLCSMYTPIC--LEDYKKPLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPEQGNP 136

  Fly   161 D-LCV-----AENTTSSAS---TAATPTRSVAKVTTRKHQTGVESPH---RNIGFVCPVQLKTPL 213
            | ||:     .|.||::.|   ....|.||..|..||     ||.|.   |..|.....|.:.|:
 Frog   137 DTLCMDYYNRTEQTTAAPSHPEPPKPPARSAPKGRTR-----VEPPRPRPRAPGCEPGCQCRAPM 196

  Fly   214 --------GMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLI 270
                    .:...::.|  .:.:|..|||..:|...|||...:|:|.|:.:|.||...||.||||
 Frog   197 VPVTNERHPLYNRVRTG--QIPNCAMPCHNPYFSPEERTFTEFWIGLWSVLCFASTFATVSTFLI 259

  Fly   271 DSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVKLGRLQMMSTITQGHRQT 334
            |..||:||||.|:||:.|||:|...|:..|.|| :.|:|..        |.|.:...|   |.:|
 Frog   260 DMERFKYPERPIIFLSACYLLVSAGYLVRLIAGHEKVACSR--------GELDLEHII---HYET 313

  Fly   335 TS---CTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTIS 396
            |.   ||::|:.:||..||:..||..|:..||||||:|||:|||...|..|||.||.||::::|:
 Frog   314 TGPALCTLVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSIKSIA 378

  Fly   397 VLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKR 461
            ||||:.|:||.::|:||||..:..:|..|::.||.|||.||::||||||:||||||:|:|..|.:
 Frog   379 VLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVIYLFIGSMFLLAGFVSLFRIRSVIKQGGTK 443

  Fly   462 TDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGSPE 526
            |||||:||:|||.||.|:.:||..::.|.|||.:|...|.:..:.:.|:| .:..|         
 Frog   444 TDKLEKLMIRIGIFSVLYTVPATIVVACFFYEQHNRQGWEVAHNCNSCQP-EVAQP--------- 498

  Fly   527 ARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQAYVXYETG 586
            .||.:.:||:||...::||:||.||::|.||:.|||.|..|.......|....|....||
 Frog   499 RRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRAFCTRCCWGSKATGGSMYSDVSTG 558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzNP_001261836.1 CRD_FZ1_like 51..167 CDD:143567 62/125 (50%)
Frizzled 237..564 CDD:279827 151/330 (46%)
fzd8NP_001090860.2 CRD_FZ8 23..147 CDD:143570 64/132 (48%)
7tmF_FZD8 225..538 CDD:320378 152/333 (46%)
TM helix 1 234..259 CDD:320378 10/24 (42%)
TM helix 2 268..289 CDD:320378 10/20 (50%)
TM helix 3 320..342 CDD:320378 9/21 (43%)
TM helix 4 363..379 CDD:320378 8/15 (53%)
TM helix 5 401..424 CDD:320378 10/22 (45%)
TM helix 6 452..477 CDD:320378 12/24 (50%)
TM helix 7 499..524 CDD:320378 11/24 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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