Protein Alignment fz and fzd3

DIOPT Version :9

• Sequence 1: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001123382.1
• Gene: fzd3 / 100038082
• XenbaseID: XB-GENE-484322
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 553
• Identity: 220/553 - (39%)
• Similarity: 308/553 - (55%)
• Gaps: 49/553 - (8%)

  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTIL 117
            |||||:.:|:::|||.|.||||:.|..|:.|.|.:..|.|:|.:.||.|.:.|||:||.|||...
 Frog    27 CEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPMVNLECSRDFRPFLCALYAPVCMEY 91

  Fly   118 ERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRS 181
            .|...|||.||:.| ..|.|||:.:...|||.:|||:||........:.:.:.|...|..||.
 Frog    92 GRVTLPCRKLCQRAYNECFKLMEMFGVPWPEEMECSRFPDCDEPYPRMVDISLSGDVTEETPL-- 154

  Fly   182 VAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVL 246
                          :..|:.||.||.:||....:||.. :|   :.||..||..|:|...|.:..
 Frog   155 --------------AVQRDYGFWCPRELKIDPDLGYSF-LG---VRDCSPPCPHMYFRREELSFA 201

  Fly   247 RYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREP 311
            ||::|..:.||:::.|||.||||||.:|||||||.|:|.||||::|...:..|....|.|:|...
 Frog   202 RYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDKVACNGA 266

  Fly   312 FPPPVKLGRLQMMSTITQG-HRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAI 375
            .|...|      .:|:||| |.:  :||:|||.|||..||...||..|...|||||..|||.|||
 Frog   267 NPSQYK------AATVTQGSHNK--ACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAI 323

  Fly   376 ENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALF 440
            |.|:.|||..||.:|...||.:||:.|:|||.:|||||||..|..:|..|::.|||:.:.:|...
 Frog   324 EKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVQALRYFVLAPLCLDVVVGVSL 388

  Fly   441 LLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWH 505
            ||||.|||.|:|..:..:.:..|||.:.|:|||.||.|:::|.:.::||.|||......|...|.
 Frog   389 LLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGVWETTWV 453

  Fly   506 RDICKPFSIPCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQG 570
            ::.||.:.||||......|   ||...:|::|||.:::||:.|..|:.|.||...|.:|   ..|
 Frog   454 QERCKEYHIPCPYKVTQTS---RPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASF---FHG 512

  Fly   571 KEPRTRAQAYVXYETGPAGGAKSTPLTPDPEAA 603
            ::.:             ||..:|..:..:|:.|
 Frog   513 RKKK-------------AGVNESRQVLQEPDFA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	51/114 (45%)
		Frizzled	237..564	CDD:279827	143/327 (44%)
fzd3	NP_001123382.1	CRD_FZ3	23..149	CDD:143558	52/121 (43%)
		7tmF_FZD3	191..511	CDD:320161	145/333 (44%)
		TM helix 1	200..225	CDD:320161	11/24 (46%)
		TM helix 2	234..255	CDD:320161	9/20 (45%)
		TM helix 3	286..312	CDD:320161	13/25 (52%)
		TM helix 4	329..351	CDD:320161	10/21 (48%)
		TM helix 5	365..390	CDD:320161	7/24 (29%)
		TM helix 6	418..443	CDD:320161	12/24 (50%)
		TM helix 7	472..497	CDD:320161	10/27 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020