Protein Alignment Dr and NKX6-2

DIOPT Version :9

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 65/198 - (32%)
• Similarity: 91/198 - (45%)
• Gaps: 44/198 - (22%)

  Fly   321 LDGSGKSLESPHGPPPGSHMQSTILS-PAALASGHVPIRPTPFSALAAAAVAWTG----MGGGVP 380
            |.|.|..|  |.|.|   |..|.||. |...|.|.:.......:.||::|..:.|    :..|.|
Human    45 LGGLGAQL--PLGTP---HGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYP 104

  Fly   381 -------------WPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQ 432
                         |||..|..|:..|.:...|..||..:     |...:||.     |..|:.||
Human   105 KPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVLD-----KDGKKKHS-----RPTFSGQQ 159

  Fly   433 LLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAK-----------AKRLQEAEIEK 486
            :.:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|           ||:.|:::.||
Human   160 IFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEK 224

  Fly   487 IKM 489
            :|:
Human   225 LKV 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	27/63 (43%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		7/32 (22%)
		Homeobox	151..204	CDD:306543	27/57 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		6/18 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810