Protein Alignment Dr and NKX6-1

DIOPT Version :9

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 104/394 - (26%)
• Similarity: 152/394 - (38%)
• Gaps: 117/394 - (29%)

  Fly   119 PPAHHLHKTTSRLSNFSVASLLADTRPRT-PPNQAADGPQNLTSSAATSPISQASSTPPPPPASA 182
            ||...||         |:|.:.....|.. ||..|  ||.:.:||      |.:||:|.|
Human    20 PPLAALH---------SMAEMKTPLYPAAYPPLPA--GPPSSSSS------SSSSSSPSP----- 62

  Fly   183 AAQVPANTFHPAAVAHHAHLLQAAHAAAAAHAQHQAMAAQLRQQQQQADARANSPPASTSSTPSS 247
                |..|.:|..:..     .|....::..:..|.::|..........:|.:.|.||.::.||:
Human    63 ----PLGTHNPGGLKP-----PATGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSA 118

  Fly   248 TPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDEEEDSIVDIEDMNADD 312
            :|.||:..|..:.:::.|.....:...:..                                |..
Human   119 SPSGSSSSSSSSASASSASAAAAAAAAAAA--------------------------------AAS 151

  Fly   313 SPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWTGMGG 377
            ||.....||...  |..||..||||.:     .||:|.|...|...|.|.:.|.          |
Human   152 SPAGLLAGLPRF--SSLSPPPPPPGLY-----FSPSAAAVAAVGRYPKPLAELP----------G 199

  Fly   378 GVP--WPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCN-------LRKHKPNRKPRTPFTTQQL 433
            ..|  |||..|.||:            .||    |:.|.       |.|....:..|..|:.||:
Human   200 RTPIFWPGVMQSPPW------------RDA----RLACTPHQGSILLDKDGKRKHTRPTFSGQQI 248

  Fly   434 LSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAK-----------AKRLQEAEIEKI 487
            .:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|           ||:.|::|.|::
Human   249 FALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERL 313

  Fly   488 KMAA 491
            |.|:
Human   314 KGAS 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	27/63 (43%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		29/118 (25%)
		Repressor domain. /evidence=ECO:0000250	102..268		57/230 (25%)
		Homeobox	239..293	CDD:395001	27/53 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		7/24 (29%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		5/12 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810