Protein Alignment Dr and NKX2-2

DIOPT Version :10

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 64/207 - (30%)
• Similarity: 86/207 - (41%)
• Gaps: 48/207 - (23%)

  Fly   301 SIVDIEDMNADDSPRSTPDGLDGSGKSLESP----HGPPPGSHMQSTILSPAAL-ASGHVPIR-- 358
            |:.||.|:         ||..|..|...|.|    .||.|..  ::..|...|| |...:|::
Human    11 SVKDILDL---------PDTNDEEGSVAEGPEEENEGPEPAK--RAGPLGQGALDAVQSLPLKNP 64

  Fly   359 -----PTPFSALAAAA----VAWTGMGGGVPWPGTRQMPP-----FGPPGMFPGAGFGGDANEPP 409
                 ..|::...|:.    .:..|:..|.|...:....|     ..|.......|.||||.:
Human    65 FYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGK-- 127

  Fly   410 RIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRA 474
                       .||.|..|:..|...||::||:::|||..||...:|.:|||.|||||||||.|.
Human   128 -----------KRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRY 181

  Fly   475 KAKRLQEAEIEK 486
            |.||   |..||
Human   182 KMKR---ARAEK 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	29/55 (53%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		16/55 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		10/53 (19%)
		Homeodomain	129..185	CDD:459649	29/55 (53%)