DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dr and MSX1

DIOPT Version :9

Sequence 1:	NP_477324.1	Gene:	Dr / 45285	FlyBaseID:	FBgn0000492	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_002439.2	Gene:	MSX1 / 4487	HGNCID:	7391	Length:	303	Species:	Homo sapiens

Alignment Length:	319	Identity:	120/319 - (37%)
Similarity:	144/319 - (45%)	Gaps:	101/319 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 SPPASTSSTPSST---------PLGSALGSQGNVASTPAKNERHSPLGSHTD--------SELEY 283
            :|.|..:|.|...         |.|...|...:.|:..|     :.:|:..:        |.|.:
Human     2 APAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATA-----AAMGADEEGAKPKVSPSLLPF 61

  Fly   284 DEEMLQDHEADHDEEEDSIVDIEDMNADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPA 348
            ..|.|.   |||.:.          .|.:|..:..:|:..:|.|.: |.|.||||
Human    62 SVEALM---ADHRKP----------GAKESALAPSEGVQAAGGSAQ-PLGVPPGS---------- 102

  Fly   349 ALASGHVPIRPTPFSALAAAAVAWTGMGGGV--------------------PWPGTRQMPPFGPP 393
             |.:...|..|.|....:.         ||:                    ||   .|.|.|.||
Human   103 -LGAPDAPSSPRPLGHFSV---------GGLLKLPEDALVKAESPEKPERTPW---MQSPRFSPP 154

  Fly   394 GMFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSL 458
               |....     .||  .|.|||||.||||||||||.|||:||:|||:||||||||||||||||
Human   155 ---PARRL-----SPP--ACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSL 209

  Fly   459 RLTETQVKIWFQNRRAKAKRLQEAEIEKIKMAA------------LGRGAPGAQWAMAG 505
            .||||||||||||||||||||||||:||:||||            ...|.|.|..|.||
Human   210 SLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAG 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	47/52 (90%)
MSX1	NP_002439.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..55		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..117		17/69 (25%)
		PTZ00449	<105..>248	CDD:185628	85/164 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..174		17/53 (32%)
		Homeobox	175..229	CDD:395001	48/53 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157215
Domainoid	1	1.000	107	1.000	Domainoid score	I6524
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000776
OrthoInspector	1	1.000	-	-		otm41028
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24338
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2894
SonicParanoid	1	1.000	-	-		X657
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830