Protein Alignment Dr and HOXA5

DIOPT Version :10

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_061975.2
• Gene: HOXA5 / 3202
• HGNCID: 5106
• Length: 270
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 70/310 - (22%)
• Similarity: 108/310 - (34%)
• Gaps: 105/310 - (33%)

  Fly   205 AAHAAAAAHAQHQAMAAQLRQQQQQADARANSPPASTSSTPSSTPLGSALGSQGNVASTPAKNER 269
            :.|..:...|:..|.:|    ....|:.|.:.|..||.| |...||..:.     ||.:|..:..
Human    61 SGHFGSGERARSYAASA----SAAPAEPRYSQPATSTHS-PQPDPLPCSA-----VAPSPGSDSH 115

  Fly   270 HSPLGSHTDSELEYDEEMLQDHEADHDEEEDSIVDIEDMNA-----DDSPRSTPDGLDGSGKSLE 329
            |....|.::|.           .|..|.....|...|.:..     :|:|.|:...      |.:
Human   116 HGGKNSLSNSS-----------GASADAGSTHISSREGVGTASGAEEDAPASSEQA------SAQ 163

  Fly   330 SPHGPPPGSHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPG 394
            |...|.|                   |.:|..:..:....::...:|              ||.|
Human   164 SEPSPAP-------------------PAQPQIYPWMRKLHISHDNIG--------------GPEG 195

  Fly   395 MFPGAGFGGDANEPPRIKCNLRKHKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLR 459
                                       ::.||.:|..|.|.|||:|...:||:...|.|.:.:|.
Human   196 ---------------------------KRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALC 233

  Fly   460 LTETQVKIWFQNRRAKAKRLQEAEIEKIKMAALGRGAPGAQWAMAGYFHP 509
            |:|.|:||||||||.|.|:  :.:::.:.|||.|           |.|.|
Human   234 LSERQIKIWFQNRRMKWKK--DNKLKSMSMAAAG-----------GAFRP 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	26/55 (47%)
HOXA5	NP_061975.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..175		28/145 (19%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	196..252	CDD:459649	26/55 (47%)