Protein Alignment Dr and HLX

DIOPT Version :10

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 100/438 - (22%)
• Similarity: 153/438 - (34%)
• Gaps: 163/438 - (37%)

  Fly   112 LQLAAVHPPAHHLHKTTSRLSNFSVASLL----ADTRPRTPPNQAADGPQNLTSSAATSPIS--- 169
            |..|||..|            :|.:|.:|    .|.      ..|.:|....:::|.|:.:.
Human    34 LDPAAVKKP------------SFCIADILHAGVGDL------GAAPEGLAGASAAALTAHLGSVH 80

  Fly   170 -----QASSTPP--PPPASAAAQVPA---NTFHPAAVAHHAHLLQAAHAAAAAHAQHQAMAAQLR 224
                 ||::..|  |.|..|.::|||   ....|.:.|:|.|           |.|.|....|.:
Human    81 PHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHH-----------HPQQQQQQQQPQ 134

  Fly   225 QQQQQADARANS--PPAS-TSSTPSSTPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEE 286
            |||.....||.:  |||| |...|:....|||          ||.:.:....|.......|:|.:
Human   135 QQQPPPPPRAGALQPPASGTRVVPNPHHSGSA----------PAPSSKDLKFGIDRILSAEFDPK 189

  Fly   287 MLQDHEADHDEEEDSIVDIEDMNADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQ---------- 341
            :         :|.:::.|:..:            |.|         |.|.|.|:.
Human   190 V---------KEGNTLRDLTSL------------LTG---------GRPAGVHLSGLQPSAGQFF 224

  Fly   342 ---------STILSPA------ALASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFG 391
                     |.||||.      ::........|.|::.|                  |:...|
Human   225 ASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVL------------------TKDTMP-- 269

  Fly   392 PPGMFPGAGFGGDANEPPRIKCNLRKHKPNRK-PRTPFTTQQLLSLEKKFREKQYLSIAERAEFS 455
                                    :.:|..|. .|..|:..|...|||:|..::|::..:|.:.:
Human   270 ------------------------QTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLA 310

  Fly   456 SSLRLTETQVKIWFQNRRAKAKRLQEAEIEKIKMAALGR----GAPGA 499
            :.|.||:.|||:||||||.|.:..:||:.:|.|....|.    |||.|
Human   311 AMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAA 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	23/56 (41%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		23/75 (31%)
		Homeodomain	273..333	CDD:459649	24/59 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		9/28 (32%)