Protein Alignment Dr and Nkx6-1

DIOPT Version :9

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 406
• Identity: 109/406 - (26%)
• Similarity: 163/406 - (40%)
• Gaps: 121/406 - (29%)

  Fly   112 LQLAAVHPPAHHLHKTTSRLSNFSVASLLADTRPRTPPNQAA-----DGPQNLTSSAATSPISQA 171
            |.:.|:..|    .::...||:..:|:|.:....:||...||     .||.:.:||      |.:
Mouse     2 LAVGAMEGP----RQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSS------SSS 56

  Fly   172 SSTPPPPPASAAAQVPANTFHPAAVAHHAHLLQ--AAHAAAAAHAQHQAMAAQLRQQQQQADARA 234
            ||:|.||..|                |:...|:  ||...::..:..|.::|..........:|.
Mouse    57 SSSPSPPLGS----------------HNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRP 105

  Fly   235 NSPPASTSSTPSSTPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDEEE 299
            :.|.||.::.||::|.||:..|..:.::|.|
Mouse   106 SMPVASGAALPSASPSGSSSSSSSSASATSA---------------------------------- 136

  Fly   300 DSIVDIEDMNADDSPRSTPDG-LDGSGK-SLESPHGPPPGSHMQSTILSPAALASGHVPIRPTPF 362
             |........|..:..|:|.| |.|..: |..||..||||.:     .||:|.|...|...|.|.
Mouse   137 -SAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLY-----FSPSAAAVAAVGRYPKPL 195

  Fly   363 SALAAAAVAWTGMGGGVP--WPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCN-------LRKH 418
            :.|.          |..|  |||..|.||:            .||    |:.|.       |.|.
Mouse   196 AELP----------GRTPIFWPGVMQSPPW------------RDA----RLACTPHQGSILLDKD 234

  Fly   419 KPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAK-------- 475
            ...:..|..|:.||:.:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|
Mouse   235 GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAE 299

  Fly   476 ---AKRLQEAEIEKIK 488
               ||:.|::|.|::|
Mouse   300 MATAKKKQDSETERLK 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	27/63 (43%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		30/122 (25%)
		Repressor domain. /evidence=ECO:0000250	102..269		60/232 (26%)
		Homeobox	240..293	CDD:278475	27/52 (52%)
		DUF3381	<291..345	CDD:288694	7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		6/21 (29%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		4/9 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810