DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dr and DLX4

DIOPT Version :9

Sequence 1:	NP_477324.1	Gene:	Dr / 45285	FlyBaseID:	FBgn0000492	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_612138.1	Gene:	DLX4 / 1748	HGNCID:	2917	Length:	240	Species:	Homo sapiens

Alignment Length:	172	Identity:	52/172 - (30%)
Similarity:	80/172 - (46%)	Gaps:	29/172 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 PPPGSHMQSTI---LSPAALASGHVPIRPTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPGM 395
            |.||......:   |:|....:...|:..:|.:|.:.........|..:.:|.|.   |..|...
Human     7 PLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAASPNLSYSRPYGHLLSYPYTE---PANPGDS 68

  Fly   396 F-----PGA---GFGGDANEP---------PRIKCNLRKHKPN------RKPRTPFTTQQLLSLE 437
            :     |.|   ...|.|..|         ||:.....:.:|.      |||||.:::.||..|.
Human    69 YLSCQQPAALSQPLCGPAEHPQELEADSEKPRLSPEPSERRPQAPAKKLRKPRTIYSSLQLQHLN 133

  Fly   438 KKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRL 479
            ::|:..|||::.|||:.::.|.||:|||||||||:|:|.|:|
Human   134 QRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKL 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	27/52 (52%)
DLX4	NP_612138.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..120		7/39 (18%)
DLX4	NP_612138.1	Homeobox	120..173	CDD:306543	27/52 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810