DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dr and DLX2

DIOPT Version :9

Sequence 1:	NP_477324.1	Gene:	Dr / 45285	FlyBaseID:	FBgn0000492	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	310	Identity:	84/310 - (27%)
Similarity:	121/310 - (39%)	Gaps:	104/310 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 STSSTPSST-------PLGSALGSQGNVASTPAKNERHS----PLGSHTDSELEYDEEMLQDHEA 293
            ||....|||       |.|...|..||.:|:.:.::...    |:.:.|||....:    |.|
Human    14 STQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTN----QQH-- 72

  Fly   294 DHDEEEDSIVDIEDMNADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIR 358
                                    |.|..|.|.|        |.:||.|....    |||   :.
Human    73 ------------------------PAGGGGGGGS--------PYAHMGSYQYQ----ASG---LN 98

  Fly   359 PTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPGMFPGAGFGGDANEP------PRIKCNLRK 417
            ..|:||.::..:.:|.........||...|.               .|||      |.|:....|
Human    99 NVPYSAKSSYDLGYTAAYTSYAPYGTSSSPA---------------NNEPEKEDLEPEIRIVNGK 148

  Fly   418 HKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRL-QE 481
            .|..|||||.:::.||.:|:::|::.|||::.||||.::||.||:|||||||||||:|.|:: :.
Human   149 PKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKS 213

  Fly   482 AEIEK--------------------------IKMAALGRGAPGAQWAMAG 505
            .||..                          :.....|.|.||:..:.||
Human   214 GEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSGGSGAG 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	30/52 (58%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		18/94 (19%)
		DLL_N	51..132	CDD:289198	25/140 (18%)
		Homeobox	155..208	CDD:278475	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810