Protein Alignment Dr and NKX6-3

DIOPT Version :10

• Sequence 1: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 63/215 - (29%)
• Similarity: 90/215 - (41%)
• Gaps: 61/215 - (28%)

  Fly   317 TPDGLDGSGKSLESPHGPPPGSHMQSTILS-PAA-----LASGHVPIRPTPFSALAAAAVAWTGM 375
            :|.|| |...:..:|||       .:.||| |.|     |.||:..:  ..|..|::..|.::..
Human    39 SPPGL-GPQLAAGTPHG-------ITDILSRPVAAPNNSLLSGYPHV--AGFGGLSSQGVYYSPQ 93

  Fly   376 GG--------------------GVPWPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKP 420
            .|                    |..|.|.||.                 :|.|..:..::.|.|
Human    94 VGNFSKAGNEYPTRTRNCWADTGQDWRGGRQC-----------------SNTPDPLSDSIHKKK- 140

  Fly   421 NRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIE 485
              ..|..||..|:.:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|.::....|
Human   141 --HTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALE-- 201

  Fly   486 KIKMAALGRGAPGAQWAMAG 505
              ..::..| |||...|.||
Human   202 --PSSSTPR-APGGAGAGAG 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	27/55 (49%)
NKX6-3	NP_001351770.1	Homeodomain	138..196	CDD:459649	29/60 (48%)