DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dr and NKX6-3

DIOPT Version :9

Sequence 1:	NP_477324.1	Gene:	Dr / 45285	FlyBaseID:	FBgn0000492	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001351770.1	Gene:	NKX6-3 / 157848	HGNCID:	26328	Length:	265	Species:	Homo sapiens

Alignment Length:	215	Identity:	63/215 - (29%)
Similarity:	90/215 - (41%)	Gaps:	61/215 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 TPDGLDGSGKSLESPHGPPPGSHMQSTILS-PAA-----LASGHVPIRPTPFSALAAAAVAWTGM 375
            :|.|| |...:..:|||       .:.||| |.|     |.||:..:  ..|..|::..|.::..
Human    39 SPPGL-GPQLAAGTPHG-------ITDILSRPVAAPNNSLLSGYPHV--AGFGGLSSQGVYYSPQ 93

  Fly   376 GG--------------------GVPWPGTRQMPPFGPPGMFPGAGFGGDANEPPRIKCNLRKHKP 420
            .|                    |..|.|.||.                 :|.|..:..::.|.|
Human    94 VGNFSKAGNEYPTRTRNCWADTGQDWRGGRQC-----------------SNTPDPLSDSIHKKK- 140

  Fly   421 NRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIE 485
              ..|..||..|:.:|||.|.:.:||:..|||..:.||.:||:|||:||||||.|.::....|
Human   141 --HTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKSALE-- 201

  Fly   486 KIKMAALGRGAPGAQWAMAG 505
              ..::..| |||...|.||
Human   202 --PSSSTPR-APGGAGAGAG 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	27/52 (52%)
NKX6-3	NP_001351770.1	Homeobox	142..195	CDD:306543	27/52 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810