DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dr and Dlx2

DIOPT Version :9

Sequence 1:	NP_477324.1	Gene:	Dr / 45285	FlyBaseID:	FBgn0000492	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_034184.1	Gene:	Dlx2 / 13392	MGIID:	94902	Length:	332	Species:	Mus musculus

Alignment Length:	298	Identity:	86/298 - (28%)
Similarity:	118/298 - (39%)	Gaps:	89/298 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 STSSTPSST-------PLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDE 297
            ||..|.|||       |.|:..|..||..|:.:.:..|.|..|.|
Mouse    14 STQITASSTYHQHQQPPSGAGAGPGGNSNSSSSNSSLHKPQESPT-------------------- 58

  Fly   298 EEDSIVDIEDMNADDSPRST----PDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIR 358
                   :....|.||...|    |.|..|.|.|        |.:||.|....    |||   :.
Mouse    59 -------LPVSTATDSSYYTNQQHPAGGGGGGAS--------PYAHMGSYQYH----ASG---LN 101

  Fly   359 PTPFSALAAAAVAWTGMGGGVPWPGTRQMPPFGPPGMFPGAGFGGDANEP------PRIKCNLRK 417
            ...:||.::..:.:|.........||...|.               .|||      |.|:....|
Mouse   102 NVSYSAKSSYDLGYTAAYTSYAPYGTSSSPV---------------NNEPDKEDLEPEIRIVNGK 151

  Fly   418 HKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRL-QE 481
            .|..|||||.:::.||.:|:::|::.|||::.||||.::||.||:|||||||||||:|.|:: :.
Mouse   152 PKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKS 216

  Fly   482 AEIEKIKMAALGRGAP--------------GAQWAMAG 505
            .||...:........|              ||...|||
Mouse   217 GEIPTEQHPGASASPPCASPPVSAPASWDFGAPQRMAG 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dr	NP_477324.1	Homeobox	424..477	CDD:278475	30/52 (58%)
Dlx2	NP_034184.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..83		20/90 (22%)
		DLL_N	54..135	CDD:289198	24/137 (18%)
		Homeobox	158..211	CDD:278475	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..272		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810