DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and cyp11a1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_694485.2	Gene:	cyp11a1 / 80374	ZFINID:	ZDB-GENE-010306-1	Length:	509	Species:	Danio rerio

Alignment Length:	513	Identity:	134/513 - (26%)
Similarity:	224/513 - (43%)	Gaps:	56/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTKLLKISCT----SRQCTFAKPYQAIPGP-RGPF-------GMGNLYNYLPGIGSYSWLRLHQA 54
            |..||::..|    :.|.:..:|:..|||. |...       .||.|.|            :|:.
Zfish    18 LKNLLQVKVTRSGRAPQNSTVQPFNKIPGRWRNSLLSVLAFTKMGGLRN------------VHRI 70

  Fly    55 GQDKYEKYGAIVRETIVPG-QDIVWLYDPKDIALLLN-ERDCPQRRSHLALAQYRKSRPDVYKTT 117
            ....::.:|.|.||.:  | .|.|::..|:|.|:|.. |...|.|.:..|...||..|...|
Zfish    71 MVHNFKTFGPIYREKV--GIYDSVYIIKPEDGAILFKAEGHHPNRINVDAWTAYRDYRNQKY--- 130

  Fly   118 GLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFL--QESRNG---GAIDMLPKL 177
            |:|...|..|...|..:.|||..||....||..::.|.::|:..:  |..|:|   ...|:...|
Zfish   131 GVLLKEGKAWKTDRMILNKELLLPKLQGTFVPLLEEVGQDFVARVNKQIERSGQKQWTTDLTHDL 195

  Fly   178 TRLNLELTCLLTFGARLQSFTAQEQDPRSRSTRLMDAAET---TNSCILPTDQGL------QLWR 233
            .:.:||....:.:|.|| .......||..:  ..:|....   |.|.:|....||      .:|:
Zfish   196 FKFSLESVSAVLYGERL-GLLLDNIDPEFQ--HFIDCVSVMFKTTSPMLYLPPGLLRSIGSNIWK 257

  Fly   234 FLETPSFRKLSQAQSYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGI 298
            ..........:||..|::::..:..|....||.. ..:::..:...:|...|:..:..:|:..|:
Zfish   258 NHVEAWDGIFNQADRYIQNIFKQWKENPEGNGKY-PGVLAILLMQDKLSIEDIKASVTELMAGGV 321

  Fly   299 DTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSAK-DELSMDALRTDITYTRAVLKESLRLNPI 362
            |:.::...:.||.:||.|::|.:|..|......:.| |.:.|..:   |...:|.|||:|||:|:
Zfish   322 DSVTFTLLWTLYELARQPDLQDELRAEISAARIAFKGDMVQMVKM---IPLLKAALKETLRLHPV 383

  Fly   363 AVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPF 427
            |:.:.|.:.:|.:...|.:|.||.|........|..|.|..|.::.|.||:.  |....:..|.|
Zfish   384 AMSLPRFITEDTVIQNYHIPAGTLVQLGVYAMGRDHQFFPKPEQYCPSRWIS--SKRQYFKSLGF 446

  Fly   428 GHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPVLIDLR 485
            |.|.|.|:.||:||..|.|.|:.:|..:. |......|:..|..|:..|:.|:::.::
Zfish   447 GFGPRQCLGRRIAETEMQIFLIHMLENFR-IEKQKQIEVRSKFELLLMPEKPIMLTIK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	118/445 (27%)
cyp11a1	NP_694485.2	p450	66..502	CDD:278495	121/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820