DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and cyp11c1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	522	Identity:	144/522 - (27%)
Similarity:	224/522 - (42%)	Gaps:	70/522 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SCTSRQCTFAKPYQAI----------PGPRGPFGMGNLYNYLPGIGSYSWL------------RL 51
            ||....|  |:|:..:          ...|.. |...|:..:|..||..|:            |:
Zfish   187 SCAGSVC--ARPHLCVRASVCVRPLHQSSRSA-GAARLFQEIPDTGSNGWMNLLRFWRDGRFSRM 248

  Fly    52 HQAGQDKYEKYGAIVRETIVPGQDIVWLYDPKDIA-LLLNERDCPQRRSHLALAQYRKSRPDVYK 115
            |:..::.:.:.|.|.||.: ..|..|.:..|.|.. |..:|...|:|.:....|.:|::|   ..
Zfish   249 HKHMEESFRRLGPIYREHL-GSQSSVNIMLPMDTGELFRSEGLHPRRMTLQPWATHRETR---RH 309

  Fly   116 TTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIR----------FLQESRNGGA 170
            :.|:...||.||...|..:.:|:....||..|:..:|.|.::|.|          |.:..::...
Zfish   310 SKGVFLKNGTEWRADRLLLNREVMVSSSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKAGQHTLT 374

  Fly   171 IDMLPKLTRLNLELTCLLTFGARLQSFTAQEQDPRSRSTRLMDAAE----TTNSCI-LPTDQGLQ 230
            :|..|.|.|..||.:|.:.:|.|:..|::   .|...|.|.:.|.|    ||...: ||....|:
Zfish   375 LDPSPDLFRFALEASCHVLYGERIGLFSS---CPSDESERFISAVERMLATTPPLLYLPPRLLLR 436

  Fly   231 ----LWRFLETPSFRKLSQAQ-----SYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDV 286
                ||....|......|.|:     ||....|......:.....|...|:.|...:.||.|:::
Zfish   437 LRASLWTTHATAWDDIFSHAEQRIQRSYQRLQARPSAAPDCSFPGVLGKLMEAGQLSLELIRANI 501

  Fly   287 VGTAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSAKDELSMDALRT--DITYT 349
                .:|:..|:|||:....|.|:.:||||:||    |..|..:.|:..:.|.|.|:.  .....
Zfish   502 ----TELMAGGVDTTAVPLQFALFELARNPDVQ----ECVRAQVLSSWQQASGDPLKALQGAPLL 558

  Fly   350 RAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQ 414
            :..:||:|||.|:.:.|.|...:|.:...|.||.||.|........|..:.|..|..|.|.||..
Zfish   559 KGTIKETLRLYPVGITVQRYPVRDIVLQNYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRWSA 623

  Fly   415 HRSA--LNPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPD 477
            ...|  ...:..|.||.|.|.|:.||:||..|.:||:.:||.::|..| |.:|:..|..||.:|:
Zfish   624 DADAGSAGGFRSLAFGFGSRQCVGRRIAENEMQLLLMHILRTFKLTVS-STEELSTKYTLILQPE 687

  Fly   478 AP 479
            .|
Zfish   688 CP 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	126/461 (27%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820