DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and si:dkey-91i10.3

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001116749.1	Gene:	si:dkey-91i10.3 / 565876	ZFINID:	ZDB-GENE-081105-124	Length:	513	Species:	Danio rerio

Alignment Length:	529	Identity:	149/529 - (28%)
Similarity:	234/529 - (44%)	Gaps:	100/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLKISCTSRQCTFAKPYQA------IPGPR--------GPFGMGNLYNYLPGIGSYSWLRLHQAG 55
            |.|..|:..:|..:....|      |.|.:        ||..:.:|| :|.|.|.:......|..
Zfish    13 LCKQDCSGIKCLTSMFLNARTTSTLIGGDKQKTMDDLDGPSFLTSLY-WLFGKGYFQTTHQMQIE 76

  Fly    56 QDKY------EKYGAIVRETIVPGQDIVWLYDPKDIALLLNER-------DCPQRRSHLALAQYR 107
            ..|.      .|||.:|         ||.:.....|..:|.:.       |.|..|.      ||
Zfish    77 HSKIYGPLWKSKYGPLV---------IVNVASADLIEQVLRQEGRHPIRTDMPHWRG------YR 126

  Fly   108 KSRPDVYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFLQ--ESRNGGA 170
            |.|...|   |.|...||||.|||:.:...:..||.|.|:...::||..:||..:.  ::..|..
Zfish   127 KLRNHAY---GPLTEMGPEWQRIRSILNPRMLKPKHVSNYTNAINGVVSDFIEKMAKLKTTKGND 188

  Fly   171 I---DMLPKLTRLNLELTCLLTFGARLQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQ-- 230
            :   |:..:|.:...|....:.|..|:...  .::.|           |.|...|....:..:
Zfish   189 VMVYDVAGELYKFAFEGISSVLFETRMGCL--NDEIP-----------EETQKFIFSVGEMFRLS 240

  Fly   231 ---------LWRFLETPSFRKLSQAQSYMESVALELV-------EENVRNGS-VGSSLISAYVKN 278
                     ||.::  |.::.......::..||.|||       :|.|:.|| |....::..:.:
Zfish   241 PIVILFPKFLWPYM--PFWKHFVAVWDHLFKVADELVQQKMTEIQEKVKTGSPVEGEYLTHLLIS 303

  Fly   279 PELDRSDVVGTAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSAKDELSMDALR 343
            .::..::|:|:..:|||||:||||...::.|||:||.||:|||||||...|.|..|...|.|..|
Zfish   304 EQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEEVVSVCPGDKTPSSDDITR 368

  Fly   344 TDITYTRAVLKESLRLNPIAVGVGRILNQDAIFSG-YFVPKGTTVVTQNMVACRLEQHFQDPLRF 407
            ..:  .:|:::|:|||.|:..|..|::.::.|..| :..||.|.....:......|..|.||..|
Zfish   369 MPL--LKAIVRETLRLYPVVPGNARVVAENEIVVGDHLFPKNTLFHLCHFAVSYDETVFPDPFAF 431

  Fly   408 QPDRWLQHRSAL--NPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMG--- 467
            .|.||::.:..|  :|:..:|||.|:|||:.||:||..|::||.||::.||:    ..|..|
Zfish   432 LPQRWIREQKQLSQHPFGSVPFGFGIRACLGRRVAELEMYLLLSRLIKRYEV----RPDPSGKTV 492

  Fly   468 ---VKTLLI 473
               .:|||:
Zfish   493 KPITRTLLV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	132/468 (28%)
si:dkey-91i10.3	NP_001116749.1	p450	52..510	CDD:278495	141/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820