DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and Cyp11b1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_036669.3	Gene:	Cyp11b1 / 500892	RGDID:	2453	Length:	499	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	136/503 - (27%)
Similarity:	221/503 - (43%)	Gaps:	85/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KPYQAIPGPRGPFGMGNLYNYLPGIGSYS---WLR----LHQAGQDK--------YEKYGAIVRE 68
            ||::|||                   .||   ||:    |.:.||:.        :::.|.|.|.
  Rat    36 KPFEAIP-------------------QYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRH 81

  Fly    69 TIVPGQDIVWLYDPKDIALLLN-ERDCPQRR------SHLALAQYRKSRPDVYKTTGLLPTNGPE 126
            : ..|..||.:..|:|...|.. |...|.|.      :|..|...|:         |:...||.:
  Rat    82 S-AGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRR---------GVFLLNGAD 136

  Fly   127 WWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFI-----RFLQESRNGGAIDMLPKLTRLNLELTC 186
            |...|.|:...:.:||::::||..||.|.::|:     |.|:......:|::...:....:|.:.
  Rat   137 WRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASH 201

  Fly   187 LLTFGARLQSFTAQEQDPRSRS-TRLMDA--AETTNSCILPTDQGLQLWRFLETPSFRK------ 242
            .:..|.|| ..|..:..|.|.: |..:.:  ..||....||.    .|.|:..|..:::
  Rat   202 FVISGERL-GLTGHDLKPESVTFTHALHSMFKSTTQLMFLPK----SLTRWTSTRVWKEHFDSWD 261

  Fly   243 -LSQ-AQSYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSYAS 305
             :|: ....:::|..||.|...::.||    ||..|....|....:...:.:|:...:|||:.:.
  Rat   262 IISEYVTKCIKNVYRELAEGRQQSWSV----ISEMVAQSTLSMDAIHANSMELIAGSVDTTAISL 322

  Fly   306 AFLLYHIARNPEVQQKLHEEARRVLPS--AKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGR 368
            ...|:.:||||:|||.|.:|:.....|  |..:.:|    :|:...||.|||:|||.|:...|.|
  Rat   323 VMTLFELARNPDVQQALRQESLAAEASIVANPQKAM----SDLPLLRAALKETLRLYPVGSFVER 383

  Fly   369 ILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPFGHGMRA 433
            |::.|.:...|.||.||.|:.......|....|..|.|:.|.|||:.:.:   :..|.||.|||.
  Rat   384 IVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRS---FQHLAFGFGMRQ 445

  Fly   434 CIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPVL 481
            |:.|||||..|.:||..:|:.:::.....:|...|...|:....:|.|
  Rat   446 CLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	124/460 (27%)
Cyp11b1	NP_036669.3	p450	42..495	CDD:278495	132/497 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910