DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	150/476 - (31%)
Similarity:	219/476 - (46%)	Gaps:	55/476 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AKPYQAIPGPRGPFGMGNLYNYLPGIGSYSWLRLHQAGQDKYEKYGAIVRETIVPGQ----DIVW 78
            |:.:..||||.   .:..|..::|| |:.....|.|..:...|.||.|.   .:||.    :.|:
  Fly    50 ARSFGEIPGPS---LLRMLSFFMPG-GALRNTNLIQMNRLMREMYGDIY---CIPGMMGKPNAVF 107

  Fly    79 LYDPKDIALLL-NERDCPQRRSHLALAQYRK-SRPDVYK-TTGLLPTNGPEWWRIRAQVQKELSA 140
            .|:|.|..:.. ||...|.|....:|..||| .||||:| ..||....|.||..||.:|...|..
  Fly   108 TYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMK 172

  Fly   141 PKSVRNFVRQVDGVTKEFIRFLQESRNGG----AIDMLPKLTRLNLELTCLLTFGARLQSFTAQE 201
            .::||..:.|:|.::||||..|:..||..    ..|...:|.....|....:....|: ...:..
  Fly   173 VQNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVALNTRM-GLLSDN 236

  Fly   202 QDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALELVEENVRNGS 266
            .||  .:.||........:.....|....:|.|.:|..|:|..:....:..:....:|..:|
  Fly   237 PDP--NADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNYIETAMR--- 296

  Fly   267 VGSSLISAYVKNP------------ELDRSDVVGTAADLLLAGIDTTSYASAFLLYHIARNPEVQ 319
                   .:.||.            |.::...|....|:|:|||||||.|...:|||:||||..|
  Fly   297 -------GFGKNDDGKTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLARNPSKQ 354

  Fly   320 QKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKG 384
            :||..|..|:||:.||.|: |....::.|.||.:||.||:..|..|..||..:|.:.|||.||:|
  Fly   355 EKLRRELLRILPTTKDSLT-DQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRG 418

  Fly   385 TTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSA-----------LNPYLVLPFGHGMRACIARR 438
            |.|:...:.....:::|.....|.|:|||:...|           .||::.||||.|.|.||.:|
  Fly   419 TGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKR 483

  Fly   439 LAEQNMHILLLRLLREYELIW 459
            :||..:..||:||||.|::.|
  Fly   484 IAELEIETLLVRLLRSYKVSW 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	140/454 (31%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	146/467 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	6	5.920