DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dib and Cyp49a1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	137/526 - (26%)
Similarity:	253/526 - (48%)	Gaps:	63/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKISCTSRQCTFAKPYQAIPGPRGPFGMGNLYNYLPGIGSYSWLRLHQAGQDKYEKYGAIVR-ET 69
            |....||......:||..:|||.....:||.:.:.|.||:|....|.:...:.:..||.:.: ..
  Fly    85 LPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGG 149

  Fly    70 IVPGQDIVWLYDPKDIA-LLLNERDCPQRRSHLALAQYRKS-RPDVY-KTTGLLPTNGPEWWRIR 131
            ::...|:::::|..:|. :...|...|.|.|..:|..|:.. |.|.: ...||:..:||:|...|
  Fly   150 LIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFR 214

  Fly   132 AQVQKELSAPKSVRNFVRQVDGVTKEF---IRFLQESRNGGAIDMLPKLTRLNLELTCLLTFGAR 193
            .:||..|..|::.:.::..::.:..||   |..:::.::....:.|.:|.:..||....::...|
  Fly   215 QEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALESVGRVSLDTR 279

  Fly   194 LQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALE-- 256
            |...:.:..:   .:.::::|..|....:...:..:.|||...|.::|...:|.....::.::
  Fly   280 LGCLSPEGSE---EAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNI 341

  Fly   257 -----------------------LVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGI 298
                                   :||..||  ..|:..::|.:             |.||.|.|:
  Fly   342 GKTMDKADADEARGLSKSEADISIVERIVR--KTGNRKLAAIL-------------ALDLFLVGV 391

  Fly   299 DTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIA 363
            ||||.|::..:|.:|:||:.|:||.:|.::|.|..:.:::.:.|. .:.|.||.:||:||:.|:.
  Fly   392 DTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLE-QMPYLRACVKETLRMRPVV 455

  Fly   364 VGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQH----------RSA 418
            :..||.|..||:.:||.|||||.|:..::|......:|.:|.||.|:|||:.          ...
  Fly   456 IANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQK 520

  Fly   419 LNPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPVLID 483
            ::|::.||||.|.|.|:.||.||..:|.||.::.|:|::.::..:....|.:..|  |.:|:...
  Fly   521 IHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYI--PQSPLNFK 583

  Fly   484 LRLRRE 489
            |.||.|
  Fly   584 LTLRDE 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	119/462 (26%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	124/479 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28158
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	7	6.930