DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and CYP27C1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001354431.1	Gene:	CYP27C1 / 339761	HGNCID:	33480	Length:	537	Species:	Homo sapiens

Alignment Length:	509	Identity:	134/509 - (26%)
Similarity:	228/509 - (44%)	Gaps:	98/509 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIPGPRGPFGMGNLYNYLPGIGSYSWLRLHQAGQDKYEKYGAIVRETIVPGQDIVWLYDPKDIAL 87
            |:||||   .:.||..:....|   :.|:|:..|....:||.|.:....| |.:|.:.|...:|.
Human    68 AMPGPR---TLANLAEFFCRDG---FSRIHEIQQKHTREYGKIFKSHFGP-QFVVSIADRDMVAQ 125

  Fly    88 LLN-ERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQV 151
            :|. |...|||.:..:..:||..|.   :.|||:...|.:|.::|:.:::.:..||.|..:..:|
Human   126 VLRAEGAAPQRANMESWREYRDLRG---RATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEV 187

  Fly   152 DGVTKEFIR--------------------------------FLQESRNGGAIDMLPKLT-----R 179
            :.|..:.|:                                .|.|||.|...:.:|:||     .
Human   188 NQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEA 252

  Fly   180 LNLELTCLLT---FGA---RLQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETP 238
            |.|..:...|   .||   .|:.|..:   |.....|..|.                |::|.:..
Human   253 LELMFSMFKTSMYAGAIPRWLRPFIPK---PWREFCRSWDG----------------LFKFSQIH 298

  Fly   239 SFRKLSQAQSYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSY 303
            ...||...|..|:           |...|...|::....:..|...::.....::||||:||||:
Human   299 VDNKLRDIQYQMD-----------RGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSF 352

  Fly   304 ASAFLLYHIARNPEVQQKLHEE-----ARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIA 363
            ..::.:|.:||:|||||.::.|     ..|.:|:|.|.       ..:...||:|||:|||.|:.
Human   353 TLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV-------PKVPLVRALLKETLRLFPVL 410

  Fly   364 VGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQ--HRSALNPYLVLP 426
            .|.||:..:|.:..||.:||||.:...:......:::|.....|:|:|||:  ....::.:..:|
Human   411 PGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIP 475

  Fly   427 FGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPV 480
            ||||:|:||.||:||..:|:::::||:.:|:..|...:.:..||..:..|..|:
Human   476 FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPI 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	124/471 (26%)
CYP27C1	NP_001354431.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820